The research program in cellular neuroscience seeks to better understand the fundamental mechanisms used by axons and dendrites to establish connections during development and regeneration of the nervous system. The development and maintenance of the nervous system involves signaling initiated by several families of growth factors, as well as selective pruning of mis-targeted axons and the programmed death of particular neurons that are overproduced within the embryo. Investigators in our program are using a variety of contemporary biochemical, molecular, and computer-assisted imaging techniques to elucidate these mechanisms.

Research efforts are focused on several key areas. Studies on the cytoskeleton of the neuron are a principal strength of the program (Dr. Baas and Dr. Gallo), and are relevant in understanding the mechanisms of neurodegenerative disorders and restoration of function following injury. Investigations of cell-cell interaction at the neuromuscular junction in vivo (Dr. Son) will provide important information on how synapses are formed and maintained. Studies aimed at understanding the roles of specific signaling molecules in the formation of connectivity patterns between neurons in the cerebellum (Dr. Baird) will elucidate the basis of nervous system formation.

All of the research in the program is conducted with the goal of providing a mechanistic understanding of basic cellular processes relevant to nervous system development and maintenance. The ultimate aim of our research is to stimulate the development of new clinical strategies for treating neuropathies and promoting regeneration of the injured nervous system.