Ph.D., (1973) University of Sciences, Philadelphia (formerly known as Philadelphia College of Pharmacy and Science). Professor of Medicine
My research area is inflammatory bowel diseases, commonly known as ulcerative colitis and Crohn’s disease. The focus of my research is to understand the basic pathways of inflammation and mechanisms of inflammation-associated colon cancer in these diseases. I am currently using several animal models. These include the dextran sulfate model of mouse colitis that has been extensively characterized by us and used in my laboratory. Using this model, in several inbred (knockouts and transgenics) and outbred mice, we are investigating how certain genes regulate inflammation and inflammation-mediated in oncogenesis in these models. Using these models, we are examing how neutrophils, adhere and diapedese to the area of inflammation in IBD what role do they play in inflammation-mediated oncogenesis.
Our second focus is to understand these diseases in pharmacological and immunological terms to discover novel anti-inflammatory therapies and chemopreventive agents. My laboratory multiple collaborations with several pharmaceutical companies to advance these drug discovery initiatives.
Selected Publications:
Su, CG, Wen X, Baily ST, Jiang W, Rangwala S, Keilbaugh S, Flanigan , S. Murthy, S Lazar, M Wu G. A novel theraphy for colitis utilizing PPAR-y ligands to igands to inhabit the epithelial inflammatory response. J Clin Inves 1999; 104:383-389.
Clapper, ML, Adrian R, Pfeiffer G, Kiod K, Leverly L, Cooper H, Murthy S. Depletion of colonic dexification enzyme activity in mice with dextran sulfate sodium-induced colitis. Aliment Phrmacol Ther 1999; 389-396.
Murthy S, Cooper H, Yoshitake GH, Meyer C, Meyer CJ, Murthy NS. Combination theraphy of pentoxifylline and TNFa monoclonal antibody in dextran sulfate-induced mouse colitis. Aliment Pharmacol Ther 1999; 13:251-260.
Murthy s, Murthy NS, Coppola D, Wood DL. The efficacy of Bay 1015 in dextran sulfate model of mouse colitis. Inflammation Res, 1997; 46:224-23 |