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 Carol Lippa Minimize

Professor of Neurology
Drexel University College of Medicine
Mail Stop 423, New College Building
245 N. 15th Street
Philadelphia  PA 19102
Tel: 215-762-4761
Fax: 215-762-3161
Email: clippa@drexelmed.edu

 

Educational History

1983: University of Massachusetts Medical School, Worcester, Massachusetts - M.D.
1978: McGill University, Montreal, Canada - B.A. in Psychology

Postgraduate Training

Intern, St. Vincent Hospital, Department of Medicine, Worcester, MA, 1983-1984
Resident, University of Massachusetts Medical Center (UMMC), Neurology, 1984-1986      
Chief Resident, UMMC, Department of Neurology, Worcester, MA, 1986-1987     
Resident in Neuropathology, UMMC, Department of Pathology, 1987-1988
Fellow in Neurobiology of Aging, UMMC, Department of Neurology, 1988-1989   
ELAM (Executive Leadership in Academic Medicine) Fellowship Program, Program for leaders in academic medicine, 2003-2004

Awards and Recognition

 

Best Doctors in America 2003-2008; Marquis Who’s Who: Who's Who in the World 2002-07, -in America 2001-08, -in Medicine and Health Care 2000-07, -in Science and Engineering 1998, 2002, 2005-07, - in American Women 2002-07, -in the East 1995. Elected, Alumni Alpha Omega Alpha Honor Medical Society 2002. Philadelphia Magazine Top Docs 2002; Philadelphia Magazine Best Docs for Women 2000; Philadelphia Magazine: Best Docs for Senior Citizens 1998. Teaching Recognition Certificate, MCP-Hahnemann University Neurology Residents, 1997; Boston Society for Neurology and Psychiatry Residents and Fellows' Presentations Second Prize 1989; Bachelor of Arts with First Class Honours in Psychology, McGill University, 1978.

Research Interests

Dr. Lippa directs the Memory Disorders Program and Dementia Research Laboratory, investigating the question of why people develop memory loss/forgetfulness, dementia and other cognitive problems. Her basic science laboratory research addresses the clinicopathological mechanisms underlying neuronal death in neurodegenerative diseases. Most of her work is focused on characterizing abnormal proteins in Alzheimer's disease and related types of dementia including Pick's disease/frontotemporal dementia, primary progressive aphasia, and Lewy body dementia. As director of the DUCOM Neurology Brain, Blood and CSF bank, Dr. Lippa has a large collection of brain tissue, blood and cerebrospinal fluid from patients with genetic and familial forms of dementia. Areas of active research focus in the laboratory include investigations involving protein abnormalities in these diseases. The research group is also interested in the consistent present loss and dysfunction of synapses, in these diseases, and the notion of inducing regeneration cascades as a strategy for treatment or prevention of these diseases. The overlying theory is that effective treatment and prevention will involve correcting protein processing abnormalities and regenerating or preserving synaptic structures. 

Dr. Lippa's clinical research looks at ways to restore or maintain memory and thinking abilities in patients with CNS diseases. As part of this, the Memory Disorders Center offers clinical trials to qualified subjects. Dr. Lippa’ s clinical trials experience dates back to the 1980's when she participated in the early clinical trials of Tacrine (Cognex), the first FDA approved Alzheimer’s medication. Dr. Lippa was recently part of a large NIA supported national study looking at agents that delay or prevent worsening of symptoms of individuals who are “forgetful” with mild cognitive impairment. The goal of the study is to identify agents that prevent dementia.

New clinical studies involve the following protocols: 

1) Alzheimer’s vaccine studies for individuals with mild-to-moderate symptoms. For details, contact Marjorie Hepler, RN at 215-762-7783.

3) A caregiver training program. This NIH-funded study provides free training to caregivers. Contact Dr. Gonzalez at 215-762-8331 for more information.

Much of Dr. Lippa’s work is collaborative; she works with biochemists, geneticists, pathologists and other physicians from within DUCOM and around the world. She has a reputation for organizing networks of individuals to work collaboratively to answer scientific questions about these diseases. Dr. Lippa is involved with international consensus panels to develop diagnostic criteria for brain diseases that affect thinking. She recently obtained NIH funding to support an International Multispecialty conference looking at the Lewy body dementias. She has over 80 original publications in this area, and does extensive editorial work, reviewing manuscripts for over 20 journals. She is the Editor-in Chief of the American Journal of Alzheimer's Disease and Other Dementias (AJADD) http://aja.sagepub.com/ and on the editorial board of Neurology and The Journal of Neuropathology and Experimental Neurology.

Publications

  1. Rutherford NJ, Baker MC, Zhang YJ , Gass JM, Stewart H, Kelley B, Kuntz K, Finch N, Crook RJP, Sorenson E, Lippa CF , Bigio E, Beach TG, Geschwind DH, Knopman D, Mitsumoto H, Petersen R, Cashman N, Hutton M, Boeve B, Graff-Radford N, Wzsolek ZK, Caselli RJ, Dickson D, Mackenzie IR, Petrucelli L, Rademakers R. Novel Mutations in TARDBP (TDP-43) in Familial Patients with Amyotrophic Lateral Sclerosis. (submitted, Plos Genetics)
  2. Irwin D, Revuelta G, Lippa CF . Clinical improvement of limb dystonia in corticobasal degeneration following a five-day lidocaine infusion: a case report. (Submitted)
  3. Gnjec A, Verdile G, Laws S, Paton A, Dhaliwal S, Miklossy J, Gandy SE, Lippa CF , Harper C, Halliday G, Martins RN. Altered apolipoprotein E levels in presenilin 1 linked Alzheimer's disease. (Submitted)
  4. Gong Y, Lippa CF , Zhu J, Rosso A, Lin Q, Rosso AL. Proteomics Analysis of Postsynaptic Density Reveals the Loss of Shank and synGap in Alzheimer's Disease Brain. (Submitted)
  5. Revuelta GJ, Rosso A, Lippa CF. Association between progranulin and β-amyloid in dementia with Lewy bodies. (in revision, 2008)
  6. Rosso A, Mossey J, Lippa CF. Caffeine – neuroprotective functions in cognition and Alzheimer's disease. (in revision, 2008)
  7. Irwins D, Lippa CF , Rosso A. Progranulin expression in ALS. (in revision, J Neurol Sci, 2007)
  8. Revuelta GJ, Rosso A, Lippa CF. Neuritic pathology as a correlate of synaptic loss in dementia with Lewy bodies. Am J Alzheimers Dis Other Demen, 23:97-102, 2008
  9. Lippa CF , Knopman DS. Dementia: Many roads but not built in a day. Neurology 68:2193-2194, 2007
  10. Lippa CF , Boeve BF, Parisi JE, Keegan MB. CPC: A 75-year-old man with cognitive impairment and gait changes. Neurology 69:1183-1189, 2007
  11. Rademakers R, Baker M, Gass J, Adamson J, Huey E, Momen P, Spina S, Coppola G, Karydas A, Stewart H, Johnson N, Hsiung GY, Kuntz K, Steinbart E, McCarty Wood E, Josephs K, Sorenson E , Womack K, Pickering-Brown SM, Lee VY, Schofield P, Ghetti B, Schellenberg JD, Beach TD, Mesulam M, Grafman J, Mackenzie I, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind D, Miller B, Wzsolek Z, Lippa C , Bigio E, Dickson D, Graff-Radford N and Hutton M. An international initiative to study Phenotypic variability associated with progranulin haploinsufficiency in patients with the common c.1477C>T (p. R493X) mutation. Lancet Neurology 6:857-68, 2007
  12. Klunk WE, Price JC, Mathis CA, Tsopelas ND, Lopresti BJ, Ziolko S, Bi W, Ikonomovic MD, Saxton J, Snitz E, Pollen DA, Moonis M, Lippa CF , Swearer J, Johnson K, Aizenstein H, DeKosky ST. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J Neurosci 27(23); 6174-6184, 2007
  13. Irwins D, Lippa CF , Swearer JM. Cognition and ALS. Am J Alzheimers Dis Other Demen ( Am J Alzheimers Dis Other Demen 22:300-312, 2007
  14. Lippa CF ; Duda JE; Grossman M; Hurtig HI; Aarsland D; Boeve BF; Brooks DJ; Dickson DW; Dubois B; Emre M; Fahn S; Farmer JM; Galasko D; Galvin JE; Goetz CG; Growdon JH; Gwinn-Hardy KA; Hardy J; Heutink P; Iwatsubo T; Kosaka K; Lee VM-Y; Leverenz JB; Masliah E; McKeith IG; Nussbaum RL; Olanow CW; Ravina BM; Singleton AB; Tanner CM; Trojanowski JQ Wszolek; ZK. DLB and PDD Boundary Issues: Diagnosis, Treatment, Molecular Pathology, and Biomarkers. Neurology 68:812-819, 2007
  15. Haleem K, Lippa CF , Smith T W, Kowa H, Wu J, Abdelhak T, Iwatsubo T . Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins. Am J Alzheimers Dis Other Demen 22(2): 137-144, 2007
  16. Gliebus G, Lippa CF . The influence of beta-blockers on delayed memory function in people with cognitive impairment. Am J Alzheimers Dis Other Demen 22: 57-61, 2007
  17. Lippa CF , Emre M. Characterizing Clinical Phenotypes: The Lewy's in their Life or the Life of their Lewy's? Neurology 67(11): 1910-1911, 2006
  18. Lippa, CF. An Individualized Approach to Treatment for Alzheimer's disease, Pick's disease and other dementias. Am J Alzheimers Dis Other Demen 21(5): 354-359, 2006
  19. Dodson SE; Gearing M, Lippa CF ; Montine TJ; Levey AI; Lah JJ. LR11 expression is reduced in sporadic Alzheimer's disease but not in familial AD or PS1/APP transgenic mice. J Neuropathol Exp Neurol, 65(9): 866-872, 2006
  20. Shiarli AM, Jennings R, Shi J, Bailey K, Bigio E, Ghetti B, Arima K, Iseki E, Murayama S, Kretzchmar H, Lippa CF , Halliday G, Mackenzie J, Khan N, Ravid R, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Mann DMA. Comparative tau pathology in frontotemporal lobar degeneration and Alzheimer's disease. J N europathol Appl Neurobiol , 32: 374-387, 2006
  21. Lippa CF , Morris JC. Alzheimer neuropathology in nondemented aging: Keeping mind over matter. Neurology , 66: 1801-1802, 2006
  22. de Silva R, Lashley T, Strand K, Shiarli A, Shi J, Bailey KL, Bigio EH, Arima K, Iseki E, Murayama S, Kretzchmar H, Neumann M, Lippa C , Halliday G, MacKenzie J, Ravid1R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM , Holton J, Lees A, Davies P, Revesz T, Mann DMA. An immunohistochemical study of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific monoclonal tau antibodies. Acta Neuropathologica , 111(4):329-40 , 2006
  23. Nagarsheth MH, Viehman A, Lippa SM, Lippa CF . Notch-1 immunoexpression is increased in Alzheimer's and Pick's Disease. J Neurol Sci , 15;244(1-2):111-6, 2006
  24. Murray C, Viehman A, Lippa CF . The corpus callosum in Pick's disease, Alzheimer's disease and ALS: Gliosis implies possible clinical consequence. Am J Alzheimers Dis Other Demen 21(1):37-43, 2006
  25. McKeith IG, Dickson, DW, Lowe J, Emre, M, O'Brien JT, Feldman H, Cummings J, Duda, JE, Lippa CF , Perry, EK, et al. for the Consortium on DLB. Dementia with Lewy Bodies: Diagnosis and Management: Third Report of the DLB Consortium. Neurology 65(12):1863-72, 2005
  26. Lippa SM , Lippa CF, Mori H. Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: T he impact of beta-amyloid burden. Am J Alzheimers Dis Other Demen 20: 315-318, 2005
  27. Popescu A, Lippa CF , Lee VMY, T rojanowski JQ. Lewy bodies in the amygdala: alpha-synuclein is increased in specific neurodegenerative diseases. Arch Neurol 61: 1915-1919, 2004.
  28. Lippa CF . Synaptophysin immunoreactivity in Pick's disease: Comparison with Alzheimer's disease and dementia with Lewy bodies. Am J Alzheimers Dis Other Demen 19: 341-344, 2004
  29. Nunomura A, Chiba S, Lippa CF , Cras P, Kalaria RN, T akeda A, Honda K, Smith MA, and Perry G. Increased Neuronal RNA oxidation in familial Alzheimer disease. Neurobiology of Disease 17:108-113, 2004
  30. McKeith I, Mintzer J, Aarsland D, Burn D, Chiu H, Cohen-Mansfield J, Dickson D, Dubois B, Duda J, Feldman H, Gauthier S, Halliday G, Lawlor B, Lippa CF , Lopez O, Machado J, O'Brien J, Playfer J, Reid W. Dementia with Lewy bodies. Lancet Neurology , 3:19-28, 2004
  31. Lippa CF , Dickson DW. Hippocampal sclerosis dementia: Expanding the phenotype of the frontotemporal dementias? Neurology 63:414-415, 2004
  32. Nee LE, Tierney, MA, Lippa CF . Genetic aspects of Alzheimer's disease, Pick's disease and other dementias. Am J Alzheimers Dis Other Demen 19:219-225, 2004
  33. Popescu A, Lippa CF . Parkinsonian syndromes: Parkinson's disease, dementia with Lewy bodies and progressive supranuclear palsy. Clinical Neuroscience Research 3:461-468, 2004
  34. Zhukareva V, Sundarraj S, Mann D, Sjogren M, Blenow K, Clark CM, McKeel DW, Goate A, Lippa CF , Vonsattel P, Growdon JH, T rojanowski JQ, Lee VMY. Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: a follow up study. Acta Neuropathol (Berl). 105:469-76, 2003
  35. Lippa CF , McKeith I. Dementia with Lewy bodies: improving diagnostic criteria. Neurology 60:1571-1573, 2003
  36. Rogan S, Lippa CF . Alzheimer's disease and other dementias. Am J Alzheimers Dis Other Demen 17:1-7, 2002
  37. Dickson DW, Bergeron C, Chin SS, Duyckaerts C, D. Horoupian D, K. Ikeda K, K. Jellinger K, Lantos PL, Lippa CF , Mirra SS, Tabaton M, Vonsattel JP, Wakabayashi K, Litvan I. Office of Rare Diseases Neuropathologic criteria for corticobasal degeneration. J Neurol Exp Neuropathol 61:935-946, 2002
  38. Russo C, Schettini G, Saido TC, Hulette C, Lippa C , Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK. Alzheimer's disease: Molecular consequences of presenilin-1 mutation. Nature 411:655, 2001
  39. Carter J, Lippa CF . Beta-amyloid, neuronal death and Alzheimer's disease. Current Molecular Medicine 1:733-737, 2001
  40. McKhann GM, Albert MS, Grossman M, Miller B, Dickson D, Trojanowski JQ and the Workgroup on frontotemporal dementia and Pick's disease. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurology 58: 1803-1809, 2001
  41. Mann DMA, Pickering-Brown S, Takeuchi A, Iwatsubo T, and the members of the FAD Pathology Study Group. Amyloid angiopathy and variability in amyloid deposition is determined by mutation position in PS-1 linked Alzheimer's disease. Am J Pathol 158(6):2165-75, 2001
  42. Lippa CF , Schmidt ML, Trojanowski JQ, Lee VMY. Alpha-synuclein and familial Alzheimer's disease: Epitope mapping parallels DLB and Parkinson's disease. Arch Neurol 58:1817-1820, 2001
  43. Cataldo A, Rebeck W, Ghetti B, Hulette C, Lippa CF , Van Broeckhoven C, van Duijn C, Cras P, Bogdanovic N, Bird T, Peterhoff BS, Nixon R. Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders. Ann Neurol 50:661-665, 2001
  44. Nee LE, Lippa CF . Inherited Alzheimer's disease PS-1 olfactory function: A 10 year follow up study. Am J of Alzheimer's Disease Other Demen 16:83-84, 2001
  45. Shafiq M, Nee LE, Grafman J, Tresser N, Lee VM, Trojanowski JQ, Lippa CF . Frontotemporal Dementia: Report of a Familial Case. Neurology 56:S31-S43, 2001
  46. Ishii K, Lippa CF , Tamaoka A, Miyatakel F, Ozawa K, Takaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St. George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns N, Farrer LA, Mori H. Distinguishable effects of presenilin-1 and APP717 mutations on cerebral amyloid plaque deposition. Neurobiol Aging 22:367-76, 2001
  47. Lippa CF , Schmidt ML, Bird T, Nochlin D, Hulette C, Nee LE, Mori H, Lee VM-Y, Trojanowski JQ. AMY plaques in familial Alzheimer's disease: comparison with sporadic Alzheimer's disease. Neurology 54:100-104, 2000
  48. Russo C, Schettini TC, Saido TC, Hulette C, Lippa CF , Lannfelt L, Chen SG, Ghetti B, Gambetti P, Tabaton M, Teller JK. Presenilin-1 mutations in Alzheimer's disease. Nature 405:531-532, 2000
  49. Lippa CF , Swearer JM, Kane KJ, Nochlin D, Bird TD, Ghetti B, Nee LE, St. George-Hyslop PH, Pollen DA, Drachman DA. Familial Alzheimer's disease: Site of mutation influences clinical phenotype. Ann Neurol 48:376-379, 2000
  50. Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Dole K, Lippa CF , Bird TD, Nochlin D, Andreadis A, Nixon RA. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine 10:878-91, 2000
  51. Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF , Ono S, Okazawa H. JNK activation is associated with intracellular beta-amyloid accumulation. Brain Res Mol Brain Res . 85:221-233, 2000
  52. Mehring B, Lin J, Wilson D, Lippa CF . Frontotemporal dementia with ubiquitinated inclusions: A Case study of the regional distribution of hippocampal pathology. Am J of Alzheimer's Disease 15:277-283, 2000
  53. Lippa CF , Zhukareva V, Kawarai T, Uryu K, Shafiq M, Nee LE, Grafman J, Liang Y, St. George-Hyslop PH, Trojanowski JQ, Lee VMY. Frontotemporal dementia with novel tau pathology and a Glu342Val tau mutation. Ann Neurol 48:850-858, 2000
  54. Lippa CF , Schmidt ML, Lee VM-Y, Trojanowski JQ. Antibodies to Alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann Neurol 45:353-357, 1999
  55. Nee LE, Lippa CF . Alzheimer's disease in 22 twin pairs - 13 year follow up: Hormonal, infectious and traumatic factors. Dementia 10:148-151, 1999
  56. Lippa CF , Flanders KC, Croul S. TGF-beta receptors I and II immunoexpression in Alzheimer's disease: A comparison with aging and progressive supranuclear palsy. Neurobiol Aging 19:527-533, 1999
  57. Lippa CF , Smith TW, Perry E. Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology. J Neural Transm 106:525-535, 1999
  58. Lippa CF , Smith TW, Mann DMA, Ozawa K, Ishii K, Arawaka S, Mori H. Beta-amyloid -40 and -42 deposition in dementia with Lewy bodies: A comparison with Alzheimer's disease and aging. Arch Neurol 56:1111-1118, 1999
  59. Okazawa H, Waragai M, Masaki T, Takeuchi S, Imafuku I, Kawabata M, Hirai S-I, Ohno S, Nee LE, Lippa CF , Imagawa M, Kanazawa I. Presenilin 1 suppresses transcriptional activation by c‑jun homodimers via the function of QM/Jif‑1. J Cell Biol 147:121-134, 1999
  60. Lippa CF . Familial Alzheimer's disease: Genetic influences on the disease process. Int J Mol Med 4:529-536, 1999
  61. Lippa CF . Mechanism's underlying CNS degenerative diseases. Proceedings for the North American Neuro-Ophthalmology Society . 185-187, 1999
  62. Lippa CF . Genetic aspects of CNS degenerative diseases Proceedings for the North American Neuro-Ophthalmology Society 189-194, 1999
  63. Flanders KC, Ren RF, Lippa CF . Transforming growth factor-betas in neurodegenerative disease. Progress in Neurobiology 54:71-85, 1998
  64. Lippa CF , Koffler S. Dementia with Lewy bodies: Review of a common subtype of dementia. In: Facts and Research in Gerontology 203-212, 1998
  65. Lippa CF , Smith TW, B O'Connell, Swearer J. The dementia patient with Parkinsonism: Alzheimer's disease is more common than dementia with Lewy bodies. Am J Alzheimer's Disease 13:229-235, 1998
  66. Lippa CF , Johnson R, Smith TW. The medial temporal lobe in dementia with Lewy bodies: A comparative study with Alzheimer's disease. Ann Neurol 43:102-106, 1998
  67. Lippa CF , St. George-Hyslop PH, Nee LE. Amyloid-beta-42 precedes other pathology in familial Alzheimer's disease. The Lancet 352:1117-1118, 1998
  68. Lippa CF , Fujiwara H, Mann DMA, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St. George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns N, Lee VM-Y, Iwatsubo T, Trojanowski JQ. Lewy bodies contain altered Alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. AM J Path 153:1365-1370, 1998
  69. Lippa CF , Pulaski-Salo D, Dickson DW, Smith TW. Alzheimer's disease, Lewy body disease and aging: A comparative study of the perforant pathway. J Neurol Sci 147:161-166, 1997
  70. Lippa CF , Saunders AM, Smith TW, Pulaski-Salo D, Roses AD. Apolipoprotein E-E2 and Alzheimer's disease: genotype influences pathologic phenotype. Neurology 48:515-519, 1997
  71. Farrer et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1278:1349-1356, 1997
  72. Flanders KC, Lippa CF . TGF-beta2 in chronic neurodegenerative disease. Neural Notes 2:8-10, 1996
  73. Vodovotz Y, Lucia MS, Flanders KC, Chesler L, Smith TW, Weidner J, Mumford R, Nathan C, Roberts AB, Lippa CF , Sporn MB. Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J Exp Med 184:1425-1433, 1996
  74. Lippa CF , Saunders AM, Smith TW, Swearer JM, Drachman DA, Ghetti B, Nee L, Pulaski-Salo DP, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson MD, Farlow M, Hyman BT, St George-Hyslop P, Roses AD, Pollen DA. Familial Alzheimer's disease: neuropathology cannot exclude a final common pathway. Neurology 46:406-412, 1996
  75. Lippa CF , Smith TW, Saunders AM, Crook R, Pulaski-Salo D, Davies P, Hardy J, Roses AD, Dickson D. Apolipoprotein E genotype and Lewy body disease. Neurology 45:97-103, 1995
  76. Paskavitz JF, Lippa CF , Hamos JE, Pulaski-Salo DP, Drachman DA. Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease. J Geriatr Psychiatry Neurol 8:32-37, 1995
  77. Smith TW, Lippa CF . Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol 54:297-303, 1995
  78. Lippa CF , Smith TW, Nee L, Robitaille Y, Crain B, Dickson D, Pulaski-Salo D, Pollen DA. Cortical Lewy bodies associated with familial Alzheimer's disease: Is there a genetic susceptibility factor? Dementia 6:191-194, 1995
  79. Cataldo A, Barnett JL, Berman SA, Quarless S, Bursztajn S, Lippa CF , Nixon RA. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early upregulation of the endosomal-lysosomal system. Neuron 14:671-680, 1995
  80. Flanders KC, Lippa CF , Smith TW, Pollen MB , Sporn MB . Altered expression of TGF-ß in Alzheimer's disease. Neurology 45:1561-1569, 1995
  81. Seshadri S, Drachman DA, Lippa CF . Apolipoprotein E-E4 allele and the lifetime risk of Alzheimer's disease. What physicians know and what they should know. Arch Neurol 52:1074-1079, 1995
  82. Lippa CF , Flanders KC, Smith TW. Transforming growth factor-beta: neuronal and glial expression in CNS degenerative diseases. Neurodegeneration 4:425-432, 1995
  83. Lippa CF , Smith TW, Swearer J. Alzheimer's disease and Lewy body disease: a comparative clinicopathologic study. Ann Neurol 35:81-88, 1994
  84. St. George-Hyslop P, Crapper McLachlan D, Tsuda T, Rogaev E, Karlinsky H, Lippa CF , Pollen D. Alzheimer's disease and possible gene interaction. Science 263:537, 1994
  85. O'Donnell BF, Cohen RA, Hokama H, Cuffin BN, Lippa CF , Shenton ME, Drachman DA. Electrical source analysis of auditory ERPs in medial temporal lobe amnestic syndrome. EEG and Clin Neurophys 87:394-402, 1993
  86. Lippa CF , Pearson D, Smith TW. Cortical tubers demonstrate reduced immunoreactivity for synapsin I. Acta Neuropathol (Berl) 85:449-451, 1993
  87. Lippa CF , Hamos J, Smith TW, Pulaski-Salo DP, Drachman DA. Vascular amyloid deposition in Alzheimer's disease: Neither necessary nor sufficient for the local formation of plaques and tangles. Arch Neurol 50:1088-1092, 1993
  88. Lippa CF , Koh ET, Schwartz WJ. Architecture of the suprachiasmatic nuclei in BALB/c and C57BL/6 inbred mouse strains. Brain Res Bulletin 28:347-349, 1992
  89. Smith TW, Lippa CF , DeGirolami U. Immunocytochemical study of ballooned neurons in cortical degeneration with neuronal achromasia. Clinical Neuropathology 11:28-36, 1992
  90. Lippa CF , Hamos JE, DeGennaro LJ, Pulaski-Salo D, Drachman DA. Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses. Neurobiol Aging 13:405-411, 1992
  91. Drachman A, Lippa CF . The etiology of Alzheimer's disease: The pathogenesis of dementia- The role of neurotoxins. Ann NY Acad Sci 648:176-186, 1992
  92. Lippa CF , Smith TW. The indusium griseum in Alzheimer's disease: an immunocytochemical study. J Neurol Sci 111:39-45, 1992
  93. Lippa CF , Cohen R, Smith TW, Drachman DA. Primary progressive aphasia with focal neuronal achromasia. Neurology 41:882-886, 1991
  94. Lippa CF , Smith TW, DeGirolami U, Drachman DA. The indusium griseum: Is it involved in Alzheimer's disease? Neurobiol Aging 11:551-554, 1990
  95. Lippa CF , Smith TW, DeGirolami U. Lobar atrophy with pontine neuronal chromatolysis (ballooned neurons). Human Pathology 21:1076-1079, 1990
  96. Lippa CF , Smith TW, Fontneau N. Corticonigral degeneration: A clinicopathologic study of two cases. J Neurol Sci 98:301-310, 1990
  97. Lippa CF , Smith TW, DeGirolami U, Drachman DA. The indusium griseum in Alzheimer's disease. Ann Neurol 26: 305, 1990
  98. Hayes E, Lippa CF , Davidson R. Paragangliomas of the cauda equina. AJNR 10:45-47, 1989
  99. Lippa CF , Abroms I, Davidson R, DeGirolami U. Congenital choroid plexus papilloma of the fourth ventricle. J Child Neurol 4:127-130, 1989
  100. Lippa CF , Smith T. Chromatolytic neurons in Werdnig-Hoffman disease contain phosphorylated neurofilaments. Acta Neuropathol (Berl) 17:91-94, 1988
  101. Lippa CF , Chad D, Smith T, Kaplan M, Hammer K. Neuropathology associated with cryoglobulinemia. Muscle and Nerve 9:626-631, 1986
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