Professor
Department: Neurology Control
Division/Office: Neurology Control
---------- Office Address ---------
Neurology Control
New College Building
245 N 15th St
Philadelphia , 19102
Office Phone: 215-762-1869
Drexel U. E-mail: guillermo.alexander@drexel.edu
DrexelMed E-mail: Guillermo.Alexander@DrexelMed.edu
Education:
1968 B.S. in Electrical Engineering, University of Miami, Coral Gables, Fl.
1974 M.S. in Biomedical Engineering, University of Miami, Coral Gables, Fl.
1982 Ph.D. in Biomedical Engineering, University of Texas, Austin, Tx.
Publications:
Book Chapters
1. Fariello RG, Golden GT, Reyes PF, Alexander GM and Schwartzman RJ: Metabolic correlates of GABAmimetic induced EEG abnormalities. In: Neurotransmitters, Seizures and Epilepsy II, Fariello RG, Engle J, Lloyd KG and Quesney LF (eds). Raven Press, New York. pp 245-252, 1984.
2. Brainard GC, Vaughan MK, Reiter RJ, Bertoni JM, Sprenkle PM and Alexander GM: Effect of light wavelength on the seasonal collapse of the male Syrian hamster reproductive system. In: The Pineal Gland Endocrine Aspects, Brown GM and Wainwright SD (eds). Pergamon Press, New York. Chapter 25, pp 175-181, 1985.
3. Schwartzman RJ and Alexander GM: Changes in the local cerebral metabolic rate for glucose in the MPTP primate model of Parkinson's disease. In: Advances in Neurology, Yahr MD and Bergmann KJ (eds). Raven Press, New York. 45:171-173, 1986.
4. Schwartzman RJ and Alexander GM: The Scientific Basis of Parkinsonian Syndromes. In: Pathology of the Aging Human Nervous System, Second Edition. S. Duckett and J de la Torre (eds). Oxford University Press, Oxford. Chapter 10, pp 309-321, 2001.
Abstracts
1. Schwartzman RJ, Kogure K, Alexander GM: Neuroanatomical mapping by simultaneous 14C-2-deoxyglucose uptake and ATP depletion. Neurology 28 (4):277, 1978.
2. Alexander GM, Hosek RS: Microprocessorized laboratory physiologic data system. Proceedings, 31st Annual Conference on Engineering in Medicine and Biology 20:157, 1978.
3. Hosek RS, Alexander GM: Microprocessor based clinical data system. Proceedings, 31st Annual Conference on Engineering in Medicine and Biology 20:23, 1978.
4. Carrol FB, Sutton CH, Hosek RS, Alexander GM: Microwave uses in hyperthermia. Proceedings, 31st Annual Conference on Engineering in Medicine and Biology 20:299, 1978.
5. Schwartzman RJ, Greenberg J, Reivich M, Klose KJ, Alexander GM: The quantitative 2-deoxyglucose technique in functional neuroanatomical mapping. 31st Annual Meeting, American Academy of Neurology, April, 1979.
6. Alexander GM, Schwartzman RJ, Khan T, Kogure K: ATP distribution in the intact and experimentally injured spinal cord. The American Association of Neuropathologists, Kansas City, January, 1979.
7. Schwartzman RJ, Yu J, Alexander GM, Greenberg J, Reivich M, Klose J: Quantitative 2-deoxyglucose mapping of the cerebellum. Annals of Neurology 6:165-166, 1979.
8. Schwartzman RJ, Yu J, Alexander GM, Greenberg J, Reivich M: 14C-2-deoxyglucose utilization in the cerebellum of the monkey during a conditioned arm movement. Society for Neuroscience, November, 1979.
9. Schwartzman RJ, Alexander GM, Bell RD: 14C-2-deoxyglucose analysis of precentral and supplemental motor cortex in operantly conditioned monkeys. The 32nd Annual Meeting of the American Academy of Neurology, New Orleans, April 1980.
10. Bertoni JM, Alexander GM, Schwartzman RJ: Metrizamide competitively inhibits hexokinase. Annals of Neurology 8:107, 1980.
11. Alexander GM, Schwartzman RJ, Bell RD, Yu J, Renthal A: Quantitative measurement of local metabolic rate for glucose utilizing tritiated 2-deoxyglucose. Annals of Neurology 8:127, 1980.
12. Bertoni JM, Alexander GM: Metrizamide competitively inhibits hexokinase. Society for Neuroscience, 1980.
13. Schwartzman RJ, Alexander GM, Klose J: The l-CMRg of the cervical spinal cord in the operantly conditioned macaque. The 33rd meeting of the American Academy of Neurology, Toronto, 1981.
14. Bell RD, Alexander GM, Schwartzman RJ, Yu J: 14C-2-deoxyglucose analysis of methylphenidate-induced steotypy in the awake rat. The 33rd Annual Meeting of the American Academy of Neurology, Toronto, April-May, 1981.
15. Bell RD, Alexander GM, Schwartzman RJ, Yu J: Analysis of drug-induced tremor utilizing 14C-2-deoxyglucose in the awake rat. Annals of Neurology 10:103, 1981.
16. Bell RD, Alexander GM, Schwartzman RJ: Cerebral metabolism of the reserpinized rodent. Neurology 32:A64, 1982.
17. Alexander GM, Rylander HG, Douglas JP, and Welsh AJ: Laser welded quartz transducer for CSF pressure measurement. Proceedings, 35th Annual Conference on Engineering in Medicine and Biology, 29:158, 1982.
18. Alexander GM, Schwartzman RJ, Bell RJ, Bertoni JM: Simultaneous autoradiographic quantification of cerebral blood flow and metabolism. Neurology 32:A196, 1982.
19. Dole WP, Alexander GM, Campbell AB, Bishop VS: Diastolic pressure-flow curves in the autoregulating and maximally dilated coronary bed: Influence of vascular capacitance. Presented at FASEB Meeting, New Orleans, l982.
20. Eidelberg E, Schwartzman RJ, Alexander GM: Cat spinal cord metabolism during walking. Neurology 33 (Suppl 2): 182-183, 1983.
21. Schwartzman RJ, Alexander GM: The lCMRg of the CNS in the NMPTP of Parkinson's disease. Neurology 34(Suppl 1):262-263, 1984.
22. Bell Rd, Alexander GM, Nguyen T, Albin M: Estimation of infarct size of CKBB isoenzyme. Neurology 34(Suppl 1):169, 1984.
23. Brainard GC, Schwartzman RJ, Alexander GM: Regional cerebral metabolism in the hypothalamus and septal region of the awake rat. Anat Rec 208:3, 1984.
24. Brainard GC, Alexander GM, Schwartzman RJ: Effect of light wavelength on the seasonal collapse of the male Syrian hamster reproductive system. J Steroid Biochemistry 20:1445, 1984.
25. Schwartzman RJ, Alexander GM: Spinal cord metabolism of the NMPTP treated monkey. Annals of Neurology 16:129-130, 1984.
26. Reyez PF, Alexander GM, Schwartzman RJ: Glial fibrillary acidic protein and histological studies in primate corpus striatum and substantia nigra after NMPTP treatment. Annals of Neurology 16:129, 1984.
27. Schwartzman RJ, Alexander GM: Local glucose metabolism of the cerebral cortex in a primate model of Parkinson's disease. Abstracts Society for Neuroscience, 10:1002, 1984.
28. Schwartzman RJ, Alexander GM, Memolo M: Changes in regional glucose metabolism in the mesocortical dopaminergic system of a primate model of Parkinson's disease. Neurology, 35:116, 1985.
29. Schwartzman RJ, Alexander GM: Changes in local cerebral metabolic rate for glucose in the CNS of MPTP treated monkeys. Symposium on MPTP, Washington DC, June, 1985.
30. Schwartzman RJ, Alexander GM: The lCMRg of the CNS in the MPTP model of Parkinson's disease. VIIIth International Symposium on Parkinson's Disease. New York, NY, June, 1985.
31. Schwartzman RJ, Eidelberg E, Alexander GM: Changes in local cerebral glucose metabolism in the walking cat. Annals of Neurology 18:148, 1985.
32. Schwartzman RJ, Eidelberg E, Alexander GM: Changes in glucose metabolism in the CNS of the walking cat. Abstracts Society for Neuroscience, 11:1031, 1985.
33. Eidelberg E, Miller AL, Schwartzman RJ and Alexander GM: Regional energy metabolic measurements with 2-deoxyglucose. Satellite Symposium, Novel Approaches to the Study of Motor Systems. Baniff, Alberta, July 10-13, 1986.
34. Alexander GM, Schwartzman RJ, and Ferraro TN: Spiperone binding and dopamine levels in the striatum of MPTP-treated monkeys. Annals of Neurology 20:149, 1986.
35. Kitt CA, D'Amato RJ, Alexander GM, Schwartzman RJ, Compton AL, John TH, Snyder SH, Price DL: Effects of chloroquine on the neurotoxicity of MPTP in monkey. Abstracts Society for Neuroscience 12:209, 1986.
36. D'Amato RJ, Alexander GM, Kitt CA, Schwartzman, Price DL and Synder SH: The role of neuromelanin in MPTP neurotoxicity. Abstracts Society for Neuroscience 12:208, 1986.
37. Alexander GM, Schwartzman RJ, D'Amato RJ, Kitt CA, Ferraro TN, Snyder SH: Metabolic, clinical and spiperone binding changes seen in MPTP-treated monkeys pretreated with chloroquine. Abstracts Society for Neuroscience 12:209, 1986.
38. Schwartzman RJ, Alexander GM, Grothusen JR, Stahl S: CNS glucose metabolic changes in the stages of the MPTP primate model of Parkinson's disease. Neurology 37 Sup1:338, 1987.
39. Alexander GM, Grothusen JR, Schwartzman RJ: Intracerebral dialysis in MPTP parkinsonian primates. Annals of Neurology 22:144-145, 1987.
40. Alexander GM, Grothusen JR, Joseph J, Knobler RL, Schwartzman RJ: Dopamine toxicity to PC-12 cells, protection by superoxide dismutase and catalase. Abstracts Society for Neuroscience Vol 13:410, 1987.
41. Schwartzman RJ, Alexander GM, Grothusen J, Wilpizeski C: Metabolic study of gyroxin, a central vestibular stimulant. Neurology 38(Suppl 1):369, 1988.
42. Knobler RL, Alexander GM, Grothusen JR, Lublin FD: Intracerebral uric acid production in brain infection with MHV-4 virus. Neurology 38(Suppl 1):121, 1988.
43. Schwartzman RJ, Alexander GM, Grothusen JR, Stahl SM: Treatment of MPTP parkinsonian monkeys with the selective D2 dopamine agonist (+PHNO). The 113th meeting of the American Neurological Association, 1988.
44. Schwartzman RJ, Alexander GM, Grothusen JR, Gzesh D, Stahl SM: The Correlation of Clinical Signs, LCMRglu and Dopamine Receptor Density To Striatal Dopamine Depletion in MPTP Parkinsonian Primates. Second Annual Symposium on Etiology, Pathogenesis, and Prevention of Parkinson's Disease, Philadelphia, 1988.
45. Alexander GM, Grothusen JR and Schwartzman RJ: Differences in the effective surface area of microdialysis probes in vivo versus in vitro. Abstracts Society for Neuroscience 14:741, 1988.
46. Alexander GM, Brainard DL, Gordon S, Grothusen J, Schwartzman RJ: Dopamine D1 and D2 receptor changes in MPTP parkinsonian primates. Abstracts Society for Neuroscience 15: 171, 1989.
47. Rolema H, Alexander GM, Grothusen JR, Matos FF, Castagnoli N: Comparisons of the effect of intracerebrally administered MPP+ in the mouse, rat and monkey: Microdialysis of dopamine and metabolites. Abstracts Society for Neuroscience 15: 137, 1989.
48. Alexander GM, Grothusen JR, Schwartzman RJ: Transport and metabolism of L-dopa in the striatum of parkinsonian primates. Annals of Neurology 28:236, 1990.
49. Boone JM, Alexander GM, Seibert JA: Personal computer fluoroscopy CT system for small animal and specimen research. The 76th Annual Meeting of The Radiological Society of North America, Chicago, November, 1990.
50. Boone JM, Tecotzky M, Alexander GM: A binary screen for single pulse dual energy radiography. Medical Physics 18: 659, 1991.
51. Bej MD, Schwartzman RJ, Sollenberger S, Grothusen JR, Alexander GM: Response of patients with reflex sympathetic dystrophy to intracutaneous injection of Substance P. American Academy of Neurology, 1991.
52. Snyder JW, Ferraro TN, Kyle ME, Grothusen JR, Alexander GM, Farber JL: N-methyl-4-phenylpyridinium (MPP+) potentiates the killing of cultured hepatocytes by catecholamines. Abstracts Society for Neuroscience 17:716, 1991.
53. Alexander GM, Schwartzman RJ, Grothusen JR, Gordon S, Brainard DL: Changes in brain catecholamines and dopamine uptake sites at different stages of MPTP parkinsonism in monkeys. Abstracts Society for Neuroscience 17:1289, 1991.
54. Golden GT, Alexander GM, Schwartzman RJ, Smith GG, Martin DS: Systemic chloroquine protects against striatal dopamine depletion induced by unilateral intra-nigral MPP+ injection in rats. Abstracts Society for Neuroscience 18:1577, 1992.
55. Alexander GM, Grothusen JR, Gordon SW, Schwartzman RJ: Effect of plasma levels of large neutral amino acids and B-adrenergic stimulation on the blood transport of L-dopa in naive and MPTP parkinsonian monkeys. Sixth Annual Symposium on Etiology, Pathogenesis, and Prevention of Parkinson's Disease, Toronto, October, 1992.
56. Alexander GM, Schwartzman RJ, Nukes TA and Grothusen JR: $2-Adrenergic agonist as adjunct therapy to L-dopa in Parkinson's disease. Neurology 43: A349, 1993.
57. Schwartzman RJ, Alexander GM, Sundo M and Grothusen JR: Functional neuroanatomical mapping of motor loops in the MPTP primate model of parkinsonism. Neurology 43: A269, 1993.
58. Alexander GM, Grothusen JR, Gordon SW and Schwartzman RJ: Reduced tyrosine and l-dopa blood to brain transport in catecholamine depleted mice. Abstracts Society for Neuroscience 20:12, 1994.
59. Hopp J, Schwartzman RJ, Grothusen JR and Alexander GM : Increased Sensory Thresholds in Patients with Reflex Sympathetic Dystrophy. Neurology 46: A227, 1996.
60. Alexander GM, Grothusen JR, Gordon SW and Schwartzman RJ: A microdialysis study of brain adrenergic modulation of glutamate reuptake. Abstracts Society for Neuroscience 22:1575, 1996.
61. Schwartzman RJ, Alexander GM, and Grothusen JR: Functional study of motor circuits in the MPTP primate model of parkinsonism. Annals of Neurology 42:348-349, 1997.
62. Alexander GM, Grothusen JR, Gordon SW and Schwartzman RJ: Microdialysis study of cortical glutamate reuptake in rats. Abstracts Society for Neuroscience 23:1789, 1997.
63. Amini S, Sawaya L, Denisova L, Alexander G and Khalili K. The role of Tat protein of HIV-1 in the pathogenesis of AIDS dementia. Neurodegenerative Disorders, Ochos Rios, Jamaica, February 22-28, 1998.
64. Alexander GM, Deitch JS, Seeburger JL, Israeli DA and Heiman-Patterson TD. Elevated Cortical ECF Glutamate in Transgenic Mice Expressing Human Mutant (G93A) SOD1. Neurology 52: A531-A532, 1999.
65. Schwarz EJ, Alexander GM, Prockop DJ and Azizi SA. Rat marrow stromal cells can be transduced to synthesize L-dopa. Sixth Annual Conference of the American Society for Neural Transplantation and Repair, Clearwater Florida, 1999.
66. Alexander GM, Seeburger JL, Deitch JS and Heiman-Patterson TD. Changes in cortical glutamate levels and its reuptake in a mouse model (G93A) of ALS. Abstract Society for Neuroscience 25: 1835, 1999.
67. Deitch JS, Alexander GM and Heiman-Patterson TD. GLT-1 dimerization in transgenic mice (G93A) expressing human mutant SOD1. Presented at the 10th International Symposium on ALS/MND, Vancouver, 1999.
68. Heiman-Patterson TD, Deitch JS and Alexander GM. Glutamate is increased but GLT-1 is unchanged in transgenic (G93A) SOD1 mice. Abstract, American Academy of Neurology, 2000.
69. Schwarz EJ, Azizi SA, Alexander GM, and Prockop DJ. Effects of vector systems on L-dopa production in engineered rat bone marrow stromal cells. Seventh Annual Conference ot the American Society for Neural Transplantation and Repair, Clearwater Florida, 2000.
70. Schwarz EJ, Azizi SA, Alexander GM, and Prockop DJ. Dopamine precursor production in marrow stromal cells engineered by different retroviral vectors. Sixth Annual Meeting of The International Society for Hematotherapy and Graft Engineering, San Diego, 2000.
71. Del Valle L, Deitch JS, Alexander GM and Heiman-Patterson TD. Progressive astrocytic activation in brain and spinal cord in a transgenic mouse model (G93A) of ALS. The 53rd meeting of the American Academy of Neurology, Philadelphia PA, May 2001.
72. Heiman-Patterson TD, Alexander GM, Deitch JS, Perreault MJ and Erwin K. Treatment of G93A Mice With Diethyldithiocarbamate. The 12th International Symposium on ALS/MND, Oakland CA, November 2001.
73. Heiman-Patterson TD, Deitch JS, Alexander GM, Blankenhorn E . Genetic background and gender influences of phenotype in the G93A SOD1 transgenic mouse model of ALS. The 54th Annual Meeting of the American Academy of Neurology, Denver CO, April 2002.
74. Alexander GM, Deitch JS, Blankenhorn E, Erwin K, Perreault MJ and Heiman-Patterson TD. Genetic background and gender influences on the expression of SOD1in the G93A transgenic mouse model of ALS. Abstract, Society for Neuroscience 2002.
75. Alexander GM, Erwin K, Byers N, Deitch JS, Blankenhorn E and Heiman-Patterson TD. Effect of Transgene Copy Number on Survival in the G93A Mouse Model of ALS The 56th Annual Meeting of the American Academy of Neurology, San Francisco CA, April 2004.
Peer-Reviewed Papers
1. Schwartzman RJ, Yu J, Alexander GM, Greenberg J, Reivich M, and Klose J: Quantitative 2-deoxyglucose mapping of the cerebellum. Trans Amer Neurol Assoc 104:1-2, 1979.
2. Alexander GM, Schwartzman RJ, Bell RD, Yu J and Renthal A: Quantitative measurement of local cerebral metabolic rate for glucose utilizing tritiated 2-deoxyglucose. Trans Amer Neurol Assoc 105:448-451, 1980.
3. Bertoni JM, Alexander GM and Schwartzman RJ: Metrizamide competitively inhibits hexokinase. Trans Amer Neurol Assoc 105:218-220, 1980.
4. Schwartzman RJ, Greenberg J, Reivich M, Klose KJ and Alexander GM: Functional metabolic mapping of a conditioned motor task in primates utilizing 14C-2-deoxyglucose. Exper Neurol 72:153-163, 1981.
5. Bertoni JM and Alexander GM: Studies on the mechanism of toxicity of metrizamide-competitive inhibition of yeast hexokinase. Biochem Pharmacol 30:1135-1138, 1981.
6. Alexander GM, Schwartzman RJ, Bell RD, Yu J and Renthal A: Quantitative measurement of local cerebral metabolic rate for glucose utilizing tritiated 2-deoxyglucose. Brain Research 223:59-67, 1981.
7. Bell RD, Alexander GM and Schwartzman RJ: Analysis of drug-induced tremor utilizing 14C-2-deoxyglucose in the awake rat. Trans Am Neurol Assoc 106:84-86, 1981.
8. Schwartzman RJ, Alexander GM, Eidelberg E and Yu JY: Changes in local metabolic rate for glucose in the intact and acutely transected spinal cord. Trans Amer Neurol Assoc 106:342-345, 1981.
9. Bell RD, Alexander GM, Schwartzman RJ and Yu J: The methylphenidate induced sterotypy in the awake rat: Local cerebral metabolism. Neurology 32:377-381, 1982.
10. Bell RD, Alexander GM and Schwartzman RJ: Methylphenidate decreases local glucose metabolism in the motor cortex. Pharmacol Biochem and Behavior 18:1-5, 1983.
11. Schwartzman RJ, Eidelberg E, Alexander GM and Yu J: Regional metabolic changes in the spinal cord related to spinal shock and later hyperreflexia in monkeys. Ann Neurol 14:33-37, 1983.
12. Shepherd AP, Perry MA, Alexander GM, Granger DN, Riedel GL, Kvietys PR and Franke CP: Computer registration of radioactive indicator-dilution curves. Am J Physiol 245: H1061-H1065, 1983.
13. Dole WP, Richards KL, Hartley CJ, Alexander GM, Campbell AB and Bishop VS: Diastolic coronary artery pressure-flow velocity relationships in conscious man. Cardiovascular Research 18: 548-554, 1984.
14. Dole WP, Alexander GM, Campbell AB, Hixson EL and Bishop VS: Interpretation and physiological significance of diastolic coronary artery pressure-flow relationships in the canine coronary bed. Circ Res 55: 215-226, 1984.
15. Alexander GM and Schwartzman RJ: Quantitative computer analysis of autoradiographs utilizing a charge-coupled device solid state camera. J Neurosci Meth 12: 29-36, 1984.
16. Schwartzman RJ and Alexander GM: Spinal cord metabolism of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey. Brain Research 337: 263-268, 1985.
17. Schwartzman RJ and Alexander GM: Changes in local cerebral metabolic rate for glucose in the MPTP primate model of Parkinson's disease. Brain Research 358: 137-143, 1985.
18. Bell RD, Alexander GM, Nguyen T and Albin MS: Quantification of cerebral infarct size by creatine kinase BB isoenzyme. Stroke 17:254-260, 1986.
19. Schwartzman RJ and Alexander GM: Changes in the local cerebral metabolic rate for glucose in the MPTP primate model of Parkinson's disease. In: MPTP: A Neurotoxin Producing a Parkinsonian Syndrome. VIIIth International Symposium on Parkinson's Disease. Academic Press, Inc. New York, pp 689-693, 1986.
20. Schwartzman RJ, Eidelberg E and Alexander GM: Asymmetrical regional changes in energy metabolism of the central nervous system during walking. Brain Research 398:113-120, 1986.
21. D'Amato RJ, Alexander GM, Schwartzman RJ, Kitt CA, Price DL and Snyder SH: Neuromelanin: A role in MPTP induced neurotoxicity. Life Sciences 40:705-712, 1987.
22. D'Amato RJ, Alexander GM, Schwartzman RJ, Kitt CA, Price DL and Synder SH: Evidence for neuromelanin involvement in MPTP-induced neurotoxicity. Nature 327:324-326, 1987.
23. Eidelberg E, Miller AL, Schwartzman RJ and Alexander GM: Measurements of regional glucose metabolism in studies of motor control. Journal of Neuroscience Methods. 21:139-144, 1987.
24. Brainard GC, Schwartzman RJ, and Alexander GM: Quantitative autoradiographic maps of local cerebral glucose metabolism in awake rats: I. Septal regional and anterior hypothalamus. J Comp Neurol 259:559-570, 1987.
25. Alexander GM, Grothusen JR and Schwartzman RJ: Flow dependent changes in the effective surface area of microdialysis probes. Life Sciences 43: 595-601, 1988.
26. Schwartzman RJ, Alexander GM, Ferraro TN, Grothusen JR and Stahl SM: Cerebral metabolism of parkinsonian primates 21 days after MPTP. Exp. Neurol 102:307-313, 1988.
27. Alexander GM, Grothusen JR, Zepeda H and Schwartzman RJ: Gyroxin, a toxin from the venom of crotalus durissus terrificus, is a thrombin-like enzyme. Toxicon, 26:953-960, 1988.
28. Rollema H, Alexander GM, Grothusen JR, Matos FF and Castagnoli N: Comparison of the effects of intracerebrally administered MPP+ (1-methyl-4-phenylpyridinium) in three species: Microdialysis of dopamine and metabolites in mouse, rat and monkey striatum. Neuroscience Letters 106:275-281, 1989.
29. Triolo AJ, Osterholm JL, Alexander GM, Bell RD and Frazer GD: Local cerebral glucose metabolism after global ischemia: Treatment by ventriculocisternal perfusion with a fluorocarbon emulsion. Neurosurgery 26:480-488, 1990.
30. Alexander GM, Brainard DL, Gordon SW, Hichens M, Grothusen JR and Schwartzman RJ: Dopamine receptor changes in untreated and (+)-PHNO-treated MPTP parkinsonian primates. Brain Research 547:181-189, 1991.
31. Boone JM, Tecotzky M, and Alexander GM: A binary screen detector system for single- pulse dual-energy radiography. Radiology 183:863-870, 1992.
32. Alexander GM, Schwartzman RJ, Brainard L, Gordon SW, and Grothusen JR: Changes in brain catecholamines and dopamine uptake sites at different stages of MPTP parkinsonism in monkeys. Brain Research 588:261-269, 1992.
33. Boone JM, Alexander GM and Seibert JA: A fluoroscopy based CT scanner for small specimen research and resident teaching. Investigative Radiology 28:539-544, 1993.
34. Snyder JW, Alexander GM, Ferraro TN, Grothusen JR and Farber JL: N-methyl-4-phenylpyridinium (MPP+) potentiates the killing of cultured hepatocytes by catecholamines. Chemico-Biological Interactions 88:209-223, 1993.
35. Alexander GM, Schwartzman RJ, Grothusen JR, Brainard L, Gordon SW: Changes in brain dopamine receptors in MPTP parkinsonian monkeys following L-dopa treatment. Brain Research 625:276-282, 1993.
36. Alexander GM, Schwartzman RJ, Grothusen JR, Gordon SW: Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood transport of L-dopa in naive and MPTP parkinsonian monkeys. Neurology 44:1491-1499, 1994.
37. Alexander GM, Schwartzman RJ, Nukes TA, Grothusen JR and Hooker MD: $2-Adrenergic agonist as adjunct therapy to L-dopa in Parkinson's disease. Neurology 44:1511-1513, 1994.
38. Alexander GM, Grothusen JR, Gordon SW and Schwartzman RJ: Intracerebral microdialysis study of glutamate reuptake in awake behaving Rats. Brain Research 766: 1-10, 1997.
39. Rappaport J, Joseph J, Croul S, Alexander GM, Del Valle L, Amini S and Khalili K. Molecular Pathway Involved in HIV-1 Induced CNS Pathology: Role of Viral Regulatory Protein, Tat. J. Leukocyte Biology, 65:458-465, 1999.
40. Schwarz EJ, Alexander GM, Prockop DJ and Azizi SA. Multipotential Marrow Stromal Cells Transduced to Produce L-dopa: Engraftment in a Rat Model of Parkinson's Disease. Human Gene Therapy, 10:2539-2549, 1999.
41. Alexander GM, Deitch JS, Seeburger JL, Del Valle L, and Heiman-Patterson TD. Elevated Cortical ECF Glutamate in Transgenic Mice Expressing Human Mutant (G93A) SOD1. J Neurochem, 74(4):1666-1673, 2000.
42. Boulos PT, Heiman-Patterson TD, Alexander GM and Tahmoush AJ. Patch Clamp Studies of the Thr1313Met Mutant Sodium Channel Causing Paramyatonia Congenita. Muscle Nerve 23:1736-1747, 2000.
43. Schwarz EJ, Alexander GM, Class R, Azizi SA, and Prockop DJ. Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-dopa in vitro and can be expanded at least 1000-fold in one passage. Gene Therapy 8:1214-1223, 2001.
44. Deitch JS, Alexander GM and Heiman-Patterson TD. Glutamate Transporter Protein Levels are Unchanged in Transgenic Mice Expressing the G93A Human Mutant SOD1 Gene. J Neurol Sci 193:117-123, 2002.
45. Alexander GM, Deitch JS, Blankenhorn E, Erwin K, Perreault MJ, Alexander B and Heiman-Patterson TD. Gender influences on survival and expression of SOD1in the G93A transgenic mouse model of ALS. (Submitted 2003).
46. Schwartzman RJ, O’Connor DM, Alexander GM, Perreault MJ and Grothusen JR. Open Label Trial of Thalidomide for Complex Regional Pain Syndrome Type I and Type II. (Submitted 2003).
47. Alexander GM, Erwin K, Byers N, Deitch JS, Augelli B, Blankenhorn E and Heiman-Patterson TD. Effect of Transgene Copy Number on Survival in the G93A Mouse Model of ALS. In Press, Molecular Brain Research 2004.
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