Jeffrey Deitch

Research Assistant Professor

Department: Neurology

---------- Office Address ---------
Rm 7126
New College Building
245 N. 15th St. MS 423
Philadelphia PA, 19102

Office Phone: 215-762-7693
E-mail: Jeffrey.Deitch@DrexelMed.edu

Education:

Rutgers University, New Brunswick, NJ, B.A., 1979 Psychology

University of Virginia, Charlottesville, Ph.D. 1986 Neuroscience

PUBLICATIONS

Deitch, J.S. and Rubel, E.W Afferent influences on brain stem auditory nuclei of the chicken: Time course and specificity of dendritic atrophy following deafferentation. J. Comp. Neurol., 229:66-79 (1984).

Baas, P.W., Deitch, J.S., Black, M.M., and Banker, G.A. Polarity orientation of microtubules in hippocampal neurons: Uniformity in the axon and nonuniformity in the dendrite. Proc. Nat. Acad. Sci., USA., 85:8335-8339 (1988).

Deitch, J.S. and Rubel, E.W Rapid changes in ultrastructure during deafferentation-induced dendritic atrophy. J. Comp. Neurol., 281:234-258 (1989).

Deitch, J.S. and Rubel, E.W Changes in neuronal cell bodies in n. laminaris during deafferentation-induced dendritic atrophy. J. Comp. Neurol., 281:259-268 (1989).

Deitch, J.S., Smith, K.L., Lee, C., Swann, J.W. and Turner, J.N. Confocal scanning laser microscope images of hippocampal neurons intracellularly labeled with biocytin. J. Neurosci. Meth., 33:61-76 (1990).

Deitch, J.S., Smith, K.L., Swann, J.W. and Turner, J.N. Parameters affecting imaging of the horseradish peroxidase-diaminobenzidine reaction product in the confocal scanning laser microscope. J. Microsc. (Lond.), 160:265-278 (1991).

Deitch, J.S., Smith, K.L., Swann, J.W. and Turner, J.N. Ultrastructural investigation of neurons identified and localized using the confocal scanning laser microscope. J. Electron Microsc. Tech., 18:82-90 (1991).

Deitch, J.S. and Banker, G.A. An electron microscopic analysis of hippocampal neurons developing in culture: Early stages in the emergence of polarity. J. Neuroscience, 13:4301-4315 (1993).

Alexander, G.M., Deitch, J.S., Seeburger, J.L., Del Valle, L. and Heiman-Patterson, T.D. Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. J. Neurochem., 74:1666-1673 (2000).

Arruda, V.R., Hagstrom, J.N., Deitch, J., Heiman-Patterson, T., Camire, R.M., Chu, K., Fields, P.A., Herzog, R.W., Couto, L.B., Larson, P.J. and High, K.A. Posttranslational modifications of recombinant myotube-synthesized human factor IX. Blood, 97:130-138 (2001).

Deitch, J.S., Alexander, G.M. and Heiman-Patterson, T.D. GLT-1 glutamate transporter levels are unchanged in mice expressing G93A human mutant SOD1. J. Neurol. Sci., 193:117-126 (2002).

Alexander, G.M., Erwin, K.L., Byers, N., Deitch, J.S., Augelli, B.J., Blankenhorn, E.P. and Heiman-Patterson, T.D. Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS. Mol. Brain Res., in press, (2004).

BOOK CHAPTERS

Rubel, E.W, Born, D.E., Deitch, J.S. and Durham, D. Recent advances toward understanding auditory system development. In: Berlin, C.I. (ed.), Hearing Science, San Diego: College-Hill Press, pp. 109-157 (1984).

Deitch, J.S. and Fischer, I. Hippocampus. In Haynes, L.W (ed.) The Neuron in Tissue Culture, IBRO Handbook Series: Methods in the Neurosciences, vol 18. Wiley:Chichester, pp 531-539 (1999).

RECENT ABSTRACTS

Arruda, V.R., Hagstrom, J.N., Herzog, R.W., Heiman-Patterson, T., Deitch, J.S., Chu, K., Couto, L.B., Larson, P.J., and High, K.A. Factor IX synthesized in dog and human muscle cells has specific activity comparable to plasma- derived factor IX. Presented at the 40th Annual Meeting of the American Society of Hematology, December, 1998.

Alexander, G.M., Deitch, J.S., Seeburger, J.L., Israeli, D.A., and Heiman-Patterson, T.D. Elevated cortical ECF glutamate in transgenic mice expressing human mutant (G93A) SOD1. Neurology 52: A531-A532, 1999.

Deitch, J.S., Seeburger, J.L., Alexander, G.M., and Heiman-Patterson, T.D. GLT-1 dimerization in transgenic mice G93A) expressing human mutant SOD1. Presented at the 10th International Symposium on ALS/MND, Vancouver, Canada, November, 1999.

Alexander, G.M., Seeburger, J.L., Deitch, J.S., and Heiman-Patterson, T.D. Changes in cortical glutamate levels and its reuptake in a mouse model (G93A) of ALS. Soc. Neurosci. Abstr., 25:1835, 1999.

Heiman-Patterson, T.D., Deitch, J.S., and Alexander, G.M. Glutamate is increased but GLT-1 is unchanged in transgenic (G93A) SOD1 mice. American Academy of Neurology, 54:A154, 2000.

Del Valle, L., Deitch J.S., Alexander, G.M., and Heiman-Patterson, T.D. Progressive astrocytic activation in brain and spinal cord in a transgenic mouse model (G93A) of ALS. Presented at the Annual Meeting of the American Academy of Neurology, Philadelphia, Apr., 2001.

Heiman-Patterson, TD, Alexander, GA, Deitch, JS, Perreault, MJ & Erwin, K. Treatment of G93A Mice with Diethyldithiocarbamate. Presented to the Association of ALS/MND Societies Meeting, Oakland, CA 2001. ALS and other Motor Neuron Diseases 2:154, 2001.

Alexander, G.M., Deitch, J.S., Blankenhorn, E., Erwin, K., Perreault, M.J., and Heiman-Patterson, T.D. Genetic background and gender influences on the expression of SOD1 in the G93A transgenic mouse model of ALS. Presented at the Annual Meeting of the Society for Neuroscience, Orlando, FL., Nov. 2002.

Heiman-Patterson, T.D., Deitch, J.S., Alexander, G.M., and Blankenhorn, E. Genetic background and gender influences on phenotype in the G93A SOD1 transgenic mouse model of ALS. 54th Annual Meeting of the American Academy of Neurology. Neurology, 58:A465, 2002.

Heiman-Patterson, T.D., Deitch, J.S., Blankenhorn, E., Erwin, K., Perreault, M.J., Alexander, B. and Alexander, G.M. Background and gender effects on survival in the SOD1(G93A) transgenic mouse model of ALS. Presented at the 14th International Symposium on ALS, Milan, Nov., 2003. ALS and other Motor Neuron Disorders, 4:Suppl 1, p.118.

Alexander GM, Erwin K, Byers N, Deitch J, Blankenhorn E, and Heiman-Patterson TD: Effect of gene copy number on survival in the G93A Mouse Model of ALS. Presented at the American Academy of Neurology, San Francisco, April, 2004.