Departments, Centers and Institutes » Clinical Depts. » Neurology » Faculty » John R. Grothusen   Search   
 John R. Grothusen Minimize

Research Assistant Professor
Neurology
New College Building
245 N. 15th St MS 423
Philadelphia, PA 19102
Tel: 856-858-0478
Email: John.Grothusen@drexelmed.edu

Education

1976: B.S., (Biology) Pennsylvania State University, University Park, PA

1983: Ph.D., (Biochemistry) Clemson University, Clemson, SC

Publications

  • Powell GL, Grothusen JR, Zimmerman JK, Evans CA and Fish WW: A re-examination of some properties of fatty acyl-CoA micelles.J.Biol.Chem., 256(24):12740-12747, 1981.
  • Hilderman RJ, Zimmerman JK, Dange CV and Grothusen JR: Characterization of a homogeneous arginyl-and lysyl-tRNA synthetase complex isolated from rat liver. J. Biol. Chem. 258(22):13592-13596, 1983.
  • Brown TM and Grothusen JR: High performance liquid chromatography of 4-nitrophenyl organophosphinates and chiral-phase separation of enantiomers. J. Chromatogr., 294:390-396, 1984.
  • Shepard M and Grothusen JR: A simple calculator program for flexible sequential sampling of insects. Bull. Ent. Soc. Amer., 30:35-37, 1984.
  • Grothusen JR and Zimmerman JK: A simple method of analyzing profiles in time-difference direct optical scanning gel chromatography. Biophys. Chem. 20:299-304, 1984.
  • Grothusen JR and Brown TM: Stereoselectivity of acetylcholinesterase, Arylester hydrolase and chymotrypsin toward 4-nitrophenyl alkyl (phenyl) phosphinates. Pestic. Biochem. Physiol., 26:100-106, 1986.
  • Grothusen JR, Bryson PK, Zimmerman JK and Brown TM: Hydrolysis of 4-nitrophenyl organophosphinates by arylester hydrolase from rabbit serum. J. Ag. Food Chem., 34(3):513- 515, 1986.
  • Alexander GM, Grothusen JR and Schwartzman RJ: Intracerebral dialysis in MPTP parkinsonian primates. Ann. Neurol., 22:144-145, 1987.
  • Alexander GM, Grothusen JR, Zepeda H and Schwartzman RJ: Gyroxin, a neurotoxin from the venom of crotalus durissus terrificus, is a thrombin-like enzyme. Toxicon, 26:953-960, 1988.
  • Knobler RL, Alexander GM, Grothusen JR and Lublin FD: Intracerebral uric acid production in brain infection with MHV-4 virus. Neurology 38:121, 1988.
  • Alexander GM, Grothusen JR and Schwartzman RJ: Flow dependent changes in the effective surface area of microdialysis probes. Life Sci., 43:595-601, 1988.
  • Schwartzman RJ, Alexander GM, Grothusen JR, and Wilpizeski C: Metabolic study of gyroxin, a central vestibular stimulant. Neurology 38:369, 1988.
  • Schwartzman RJ, Alexander GM, Ferraro TN, Grothusen JR and Stahl SM: Cerebral metabolism of parkinsonian primates 21 days after MPTP exposure. Neurol.,102:307-313, 1988.
  • Rollema, H, Alexander, GM, Grothusen JR, Matos, FF and Castagnoli, N: Comparison of the effects of intracerebrally administered MPP+ (1-methyl-4-phenylpyridinium) in three species: microdialysis of dopamine and metabolites in mouse, rat and monkey striatum. Neurosci. Lett., 106:275-281, 1989.
  • Alexander GM, Brainard DL, Gordon SW, Hichens M, Grothusen JR and Schwartzman RJ: Dopamine receptor changes in untreated and (+)-PHNO-treated MPTP parkinsonian primates. Brain Research, 547:181-189, 1991.
  • Alexander GM, Schwartzman RJ, Brainard DL, Gordon SW and Grothusen JR: Changes in brain catecholamines and dopamine uptake sites at different stages of MPTP parkinsonism in monkeys. Brain Res., 588:261-269, 1992.
  • Alexander GM, Schwartzman RJ, Grothusen JR, Brainard DL and Gordon SW: Changes in brain dopamine receptors in MPTP parkinsonian monkeys following l-dopa treatment. Brain Research, 625:276-282, 1993.
  • Snyder JW, Alexander GM, Ferraro TN, Grothusen JR and Farber JL: N-methyl-4- phenylpyridinium (MPP+) potentiates the killing of cultured hepatocytes by catecholamines. Chem.-Biol. Interactions, 88:209-223, 1993.
  • Alexander GM, Schwartzman RJ, Grothusen JR, Gordon SW: Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood transport of levodopa in naive and MPTP parkinsonian monkeys.Neurology, 44:1491-1499, 1994.
  • Alexander GM, Schwartzman RJ, Nukes TA, Grothusen JR and Hooker, MA: beta2-Adrenergic agonist as adjunct therapy to levodopa in Parkinson's disease. Neurology, 44:1511-1513, 1994.
  • Alexander GM, Grothusen JR, Gordon SW and Schwartzman RJ: Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats. Brain Research, 766: 1-10, 1997
  • Tahmoush AJ, Schwartzman RJ, Hopp JL, Grothusen JR: Quantitative sensory studies in complex regional pain syndrome type 1/RSD. Clinical Journal of Pain, 16(4):340-4,2000.
  • Singh, MK, Patel, J, Grothusen, J, Foye, PM: Complex regional pain syndromes. Review for emedicine. http://author.emedicine.com/PMR/topic123.htm
  • Schwartzman RJ, Grothusen J, Kiefer TR, Rohr P: Neuropathic central pain: epidemiology, etiology, and treatment options Archives of Neurology, Oct;58(10):1547-50, 2001
  • Schwartzman RJ, Grothusen JR: Brachial plexus traction injury: a controlled, quantitative study. submitted to Neurology
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