Professor
Neurology
219 Broad Street Building
219 N. Broad St
Philadelphia  PA 19102
Tel: (215) 762-7692
Email: Terry.Heiman-Patterson@drexelmed.edu

EDUCATION:

1969-1975
B.S.: Rensselaer Polytechnic Institute, Troy, New York

Publications

• Heiman, T.D., Satymuri, S.: Benign Cerebellar Hemmorhage. Annals of Neurology 3:336-339, 1978.
• Heiman, T.D., Bonilla, E., Schotland, D.L.: Concavalin: A Binding of the Cell Surface in Duchenne Muscle In-Vitro. Annals of Neurology 12:305-307, 1982.
• Heiman, T.D., Bonnila, E., Di Mauro, S., Schotland, D.L.: Cytochrome C-Oxidase Deficiency in a Floppy Infant. Neurology 32:898-900, 1982.
• Downey, G.P., Rosenberg, M., Caroff, S., Beck, S., Rosenberg, H., Gerber, J., Heiman-Patterson, T.D., Aaronson, M.: The Neuroleptic Malignant Syndrome: A Patient with Unique Clinical and Physiological Features. The American Journal of Medicine 77:338-340, 1984.
• Alonso, R., Heiman-Patterson, T.D., Mancall, E.L.: Cerebral Toxoplasmosis in Acquired Immune Deficiency Syndrome. Archives of Neurology 41:321, 1984.
• Heiman-Patterson, T.D., Strominger, N.L.: Morphological Changes in the Cochlear Nuclear Complex in Primate Phylogenesis and Development. Journal of Morphology 186:289-306, 1985.
• Berman, A.T., Garbarino, G.L., Rosenberg, H., Heiman-Patterson, T.D.: Muscle Biopsy: Proper Surgical Technique. Clinical Orthopedics 188:240-243, 1985.
• Heiman-Patterson, T.D., Binning, C.P.S., Tahmoush, A.J.: King Denborough Syndrome: Contracture Testing and Review of the Literature. Pediatric Neurology 1986; 2:175-178.
• Heiman-Patterson, T.D., Natter, H.M., Rosenberg, H., Fletcher, J.E., Tahmoush, A.J.: Malignant Hyperthermia Susceptibility in X-Linked Muscle Dystrophies. Pediatric Neurology, 1986; 2:356-358.
• Caroff, S.N., Rosenberg, H., Fletcher, J.E., Heiman-Patterson, T.D., Mann, S.C.: Malignant Hyperthermia Susceptibility in Neuroleptic Malignant Syndrome. Anesthesiology 1987; 67:20-25.
• Heiman-Patterson, T.D., Fletcher, J.E., Rosenberg, H., Tahmoush, A.J.: No Relationship Between Fiber Type and Halothane Contracture Test Results in Malignant Hyperthermia. Anesthesiology, 1987; 67:82-84.
• Hansman, M.L., Peyster, R.G., Heiman-Patterson, T., Greefield, V.S.: CT Demonstration of Extraocular Muscle Atrophy. Journal Computer Assisted Tomography, 1988; 12:49-51.
• Heiman-Patterson, T.D., Rosenberg, H., Fletcher, J.E., Tahmoush, A.J.: Contracture Testing for Malignant Hyperthermia in Neuromuscular Diseases. Muscle and Nerve, 1988; 38:810-812.
• Heiman-Patterson, T.D., Martino, C., Rosenberg, H., Fletcher, J., Tahmoush, A.J.: Malignant Hyperthermia in Myotonia Congenita. Neurology, 1988; 38:810-812.
• Scott, M.O., Sylvester, J.E., Heiman-Patterson, T.D., et. al.: Duchenne Gene Expression in Normal and Diseased Muscle. Science, 1988;239:1418-1420.
• Heiman-Patterson TD: Malignant Hyperthermia In: Proceedings of the 1989 Scientific Meeting of the American Society for Neurological Investigation.
• Shy, M.E., Evans, V.A., Lublin, F.D., Knobler, R.L., Heiman-Patterson, T.D., Tahmoush, A.J., Parry, G.P., Shick, P.K.: Antibodies to G.M., and GD1b in Motor Neuron Disease Patients Without Plasma Cell Dyscrasia. Annals of Neurology, 25:511-513, 1989.
• Shy, M.E., Heiman-Patterson, T.D., Parry, G.J., Tahmoush, A.J., Evans, V.A., Shick, P.K.: Lower motor neuron disease in a Patient with Autoantibodies Against GAL (Beta1-3) GHLNAC in Gangliosides GM1 and GD1b: Improvement Following Immunotherapy. Neurology 1990;40:482-844.
• Heiman-Patterson, T.D., Bird, S.J., Parry, G.J., Varga, J., Shy, M.E., Tahmoush, A.J., Edelsohn, L, Tatarian, G.T., Heyes, M.P., Garcia, C.A., Culligan, N.W.: Peripheral Neuropathy Associated with Eosinophia-Myalgia Syndrome. Annals of Neurology 28:522-528 1990.
• Varga J, Heiman-Patterson TD, Emery DL et al: Clinical Spectrum of the systemic manifestations of the Eosinophilia Myalgia Syndrome, Seminars in Arthritis and Rheumatism 19:313-328 1990.
• Miano, M.A., Bosley, T.M., Heiman-Patterson, T.D., Reed, J., Sergott, R.C., Savino, P.J., Schatz, N.J.: Factors Influencing Outcome of Prednisone Dose Reduction in Myasthenia Gravis. Neurology 41:919-920 1991.
• Tahmoush A.J., Alonso RF, Tahmoush GP, Heiman-Patterson TD: The cramp-fasciculation syndrome. A treatable hyperexcitable peripheral nerve disorder. Neurology 41:1021-1023 1991.
• Tahmoush A.J., Gillespie J.A., Hulihan J.F., Siegel D.R., Kushner H., Parry G.J., Heiman-Patterson T.D.: Correlation analysis of clinical and electrophysiologic assessments in ALS patients. EEG and Clinical Neurophysiology 31:491-496, 1991
• Noursadeghi, M., Walsh, F.S., Heiman-Patterson, T.D., Dickson, G., Trans-activation of the murine dystrophin gene in human-mouse hybrid myotubes. Elsevier Science: Volume 320, number 2, 155-159. 1993
• Heiman-Patterson, TD, Krupa T., Thompson P, Nobile-Orazio, E., Tahmoush, AJ., Shy, ME: Anti-Gal GalNAc M-Proteins Damage Human Spinal Cord Neurons Co-cultured with Muscle. Journal of the Neurological Sciences 120:338-345. 1993
• Mannion, JD., Magno, M., Buckman, P., Bailey, W., Blood, V., Heiman-Patterson, TD., Edie, RN., Rosato, FE., Techniques to Enhance Extramyocardial Collateral Blood Flow After a Cardiomyoplasty. Annals of Surgery: Volume 218, No. 4, 544-554. 1993.
• Varga, J., Heiman-Patterson, TD., Munoz, S., Love, LA., Myopathy with mitochondrial alterations in patients with primary biliary cirrhosis and antimitochondrial antibodies. American Journal of Rheumatology: Vol 36, No. 10, 1468-1475, 1993.
• Tahmoush AJ, Schaller KL, Zhang P, Hyslop T, Heiman-Patterson, TD, Caldwell JL: Muscle sodium channel inactivation defect in paramyotonia congenita with thr1313met mutation. Neuromuscular Disorders, 4:447-454, 1994.
• Tahmoush AJ, Liu JE, Amir MS, Heiman-Patterson TD: Myopathy, Antineutrophil cytoplasmic antibodies, and glomerulonephritis. Muscle and Nerve, 18:475-477, 1995.
• Vita GM, Olckers A, Jedlicka AE, George AL. Heimnan-Paterson TD, Rosenberg H, Fletcher JE, Levitt RC: Masseter muscle rigidity associated with glycine to alanine mutation in the adult muscle sodium channel -subunit (SCN4A). Anesthesiology, 82:1097-1103, 1995.
• Tsujino S, Shanske S, Martinuzzi A, Heiman-Patterson T, and DiMauro S: Two novel missence mutations (E654K,L396P) in Caucasian patients with myophosphorylase deficiency (McArdle’s disease). Human Mutation 6:276-7, 1995.
• Tartaglino LM, Heiman-Patterson TD, Friedman DP, Flanders AE: MR imaging in a case of postvaccination myelitis. Am J. Neuroradiology 16: 581-2, 1995.
• ALS CNTF Treatment Group: A double-blind placebo-controlled trial of subcutneous Recombinant Human Ciliary Neurotrophic Factor (rHCNTF) in Amyotrophic Lateral Sclerosis. Neurology, 46:1244-1249, 1996
• Fink JK and Heiman-Patterson TD for the Hereditary Spastic Paraplegia Working Group: Hereditary Spastic Paraplegia: Advances in Genetics Research. Neurology, 46:1507-1514, 1996.
• Vita GM, Olkers A, Jedlicka AE, Heiman-Patterson T, George AL, Fletcher JE, Rosenberg H, and Levitt RC: Chromosome 17 candidate gene analysis in a population refered for suspected episode of malignant hyperthermia. In Press.
• Heiman-Patterson TD, Argov Z, Chavin JM, Kalman B, DiMauro S, Bank W, and Tahmoush AJ: Familial methylprednisolone responsive mitochondrial myopathy. Muscle and Nerve 20:1219-1224, 1997.
• Stambler N, Charaton M, Cedarbaum J, and the ALS CNTF Treatment study group: Prognostic indicators of survival in ALS. Neurology, 50:66-71, 1998.
• Gottschalk A, Heiman-Patterson TD, deQuevado R, and Quinn PD: General Anesthesia for a Patient with Centronuclear Myopathy. Anesthesia.89: 1018-20,1998.
• BDNF Study Group (Phase III): A controlled trial of recombinant methionyl human BDNF in ALS. Neurlogy, 52:. 1427-1433, 1999.
• Kasarskis EJ, Scarlotta D, Hill R et al: A retrospective study of the percutaneous endoscopic gastroscopy in ALS patients during the BDNF and CNTF Trials. J Neurol Sci 169:118-129, 1999
• Cedarbaum, J,, Stambler, N, Malta E et al : The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of pulmonary function. J Neurol Sci 169:13-21, 1999
• Kleopas KA, Sherman M, Neal B, Romano G, and Heiman-Patterson TD: Bipap improves survival and rate of pulmonary function decline in patients with ALS. J Neurol Sci. 164:82-88 1999
• Alexander GM, Deitch JS, Seeberger JL, Del Valle L, and Heiman-Patterson TD: Elevated cortical ECF Glutamate in Transgenic Mice Expressing Human Mutant (G93A) SOD 1. J Neurochem, 74, 1666-1673, 2000.
• Miller RG, Anderson FA, Bradley WG et al: The ALS Patient Care Database: Goals, design, and early results. Neurology 54: 53-57 2000.
• Boulos PT, Heiman-Patterson TD, Alexander GM, Tahmoush AJ: Patch clamp studies of the THR1313Met mutant sodium channel causing paramyotonia congenita. Muscle Nerve 23:1736-1747, 2000
• Kleopas KA, Rosenberg H, and Heiman-Patterson TD: Beckers Muscular dystrophy complicated by Malignant Hyperthermia. Anesthesiology 2000; 93:1535-1537.
• Arruda VR, Hagstrom JN, Deitch J, Heiman-Patterson TD et al: Posttranslational modifications of recombinant myotube-synthesized human factor IX Blood 97: 130-138; 2001.
• Lippa CF, Heiman-Patterson TD, Gambetti P, Croul S, and Koffler S: Ubiquinated inclusions link Amyotrophic Lateral Sclerosis with frontotemporal dementia. In Press. Contemporary Neuropsychiatry Springer Verlag Tokyo pp162-168; 2001
• Zhao X Alvarado D, Rainier S, Lemons R, Hedera P, Weber C, Tukel T, Apak M, Heiman-Patterson T, Ming L, Bui M, and Fink JK: Mutations in a newly identified GTP’ase gene cause autosomal dominant hereditary spastic paraplegia Nature Genetics 29: 326-331; 2001
• Rainer S, Hedera P, Alverado D, Zhao X, Kleopas K, Heiman-Patterson T, and Fink J: Hereditary Spastic paraplegia linked to chromosome 14q11-q21: reduction of the SPG3locus interval from 5.3 to 2.7 cM. J Med Genet J Med Genet 2001.
• Mandler RN, Anderson FA, Miller RG, et al: The ALS Care Database: Insights into End-of Life Care in ALS. Als and other motor neuron disorders 2:203-208, 2001
• Deitch JS, Alexander GM, DelValle L, and Heiman-Patterson TD: GLT-1 Glutamate Transporter Levels are Unchanged in Mice Expressing G93A Human Mutant SOD1. J. Neurosci 193:117-126; 2002
• T.H. Brannagan, III, A. Pradhan, T. Heiman-Patterson, A.C. Winkelman, M.J. Styler, D.L. Topolsky, P.A. Crilley, R.J. Schwartzman, I. Brodsky, and D.E. Gladstone
• High-dose cyclophosphamide without stem-cell rescue for refractory CIDP, Neurology 2002; 58: 1856
• Cudkowicz ME, Shefner JM, Schoenfeld DA et al: A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis. Neurology 61:456-464; 2003