Professor of Pathology & Laboratory Medicine
Research Professor of Pediatrics and Neurology
Drexel University College of Medicine

Neuropathologist, St. Christopher's Hospital for Children and Hahnemann University Hospital

Section of Neurology 
St. Christopher's Hospital for Children
Erie Avenue at Front Street
Philadelphia, PA 19134

215-427-5335
215-427-5000 to page
215-427-4284 fax
christos.katsetos@drexelmed.edu

Biography and CV

Specialty Areas

General and Pediatric Neuropathology (Clinical/Diagnostic)
Experimental Neuropathology, Histochemistry and Cell Biology of the Cytoskeleton (Research)

Clinical/Diagnostic Interests

Interdisciplinary clinico-pathological approach to neuropathology with emphasis on brain tumors, perinatal hypoxic-ischemic encephalopathy, cerebrovascular disease in children, demyelinating and immune-mediated diseases of the CNS/PNS, autopsy neuropathology, skeletal muscle and nerve pathology (inflammatory myopathies and neuropathies).

My clinical interests in tumor neuropathology focus on the diagnostic/nosologic classification, and novel biological approaches to stratification of primary CNS tumors using combined morphologic, immunohistochemical and molecular techniques, and pathological-neuroimaging correlations.

Research

Experimental neuropathology; histochemistry and cell biology of the microtubule cytoskeleton in nervous system development and neoplasia; neural stem cells/neurogenesis/gliogenesis.

During the past two decades, my research has focused on cellular aspects of growth and differentiation of human embryonal tumors of the nervous system (medulloblastomas, neuroblastomas and retinoblastomas) and on molecular aspects of viral neuro-oncogenesis.

Currently, my research focuses primarily on:

• Alterations of the microtubule cytoskeleton and gamma-tubulin in human brain tumors (diffuse astrocytic gliomas/glioblastomas and medulloblastomas).
• Differential expression and subcellular sorting of tubulins and microtubule-associated proteins in neurogenesis, gliogenesis, and neural stem cells.

I am also presently involved in collaborative projects focusing on:

• Calcium and nitric oxide-mediated cytoskeletal neuronal damage during CNS hypoxia-ischemia in the newborn and neonatal seizures (using experimental animal models).
• Immunopathogenesis and neuropathogenesis of Theiler's murine-encephalomyelitis virus (TMEV)-induced demyelinating disease as a model of multiple sclerosis.
• Clinico-pathological studies covering a wide range of pediatric neuropathology topics, including brain tumors, cerebrovascular disease, epilepsy and immune-mediated CNS diseases.

Research Detail and Publications

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