Mohammad Z. Abedin

Ph.D. (1984) University of California, Los Angeles (UCLA)
Associate Professor of Surgery

Our lab is involved in the study of the molecular mechanisms of gallstone pathogenesis. We have a long-term interest in investigating the pathogenic role of gallbladder absorption in cholesterol gallstone formation. Our current research focuses on the regulation of gallbladder ion transport by second messenger systems, using a combination of biochemical, electrophysiological, immunochemical and molecular biological techniques. The results of our studies will advance our understanding of the molecular basis underlying regulation of gallbladder absorption during gallstone formation, and suggest means for the possible prevention of gallstone disease.

Selected Publications:

Abedin MZ, Narins SC, Park EH, Smith PR, and Kirkwood KS. Lovastatin alters biliary lipid composition and dissolves gallstones: A long-term study in prairie dogs. Dig. Dis. Sci. 47:2192-2210, 2002

Abedin MZ, Giurgiu DIN, Abedin ZR, Peck, EA, Su X, and Smith PR. Characterization of Na+/H+ exchanger isoform (NHE1, NHE2 and NHE3) expression in prairie dog gallbladder epithelium. J Membr. Biol 182:123-134, 2001.

Moser AJ, Giurgiu DIN, Morgenstern, KE, Abedin ZR, Roslyn JJ, and Abedin MZ. Calmodulin regulation of gallbladder ion transport becomes dysfunctional during gallstone formation in prairie dogs. Dig Dis Sci 45(7):1422-1430, 2000.

Moser AJ, Abedin MZ, Morgenstern, KE, Abedin ZR, and Roslyn JJ. Endogenous prostaglandins modulate chloride secretion by prairie dog gallbladder. J Clin Lab Med 135:82-88, 2000.

Moser AJ, Giurgiu DIN, Morgenstern, KE, Abedin ZR, Roslyn JJ and Abedin MZ. Octreotide stimulates Ca2+ secretion by the gallbladder: A risk factor for gallstones. Surgery 125:509-513, 1999.

Giurgiu DIN, Saunders-Kirkwood KD, Roslyn JJ, Abedin MZ. Sequential changes in biliary lipids and gallbladder ion transport during gallstone formation. Ann Surg 225:382-390; 1997.

Cates JA, Abedin MZ, Saunders-Kirkwood KD, Moser AJ, Giurgiu DIN, and Roslyn JJ. Protein kinase C regulates prairie dog gallbladder ion transport. Surgery 117:206-212,1995.

Moser AJ, Abedin MZ, Giurgiu D IN, Roslyn JJ. Octreotide promotes gallbladder absorption in prairie dogs: A potential cause of gallstones. Gastroenterology 108:1547-1555, 1995

Roslyn JJ, Abedin MZ, Saunders KD, Cates JA, Strichartz SD, Alperin M, Fromm M and Palant CE. Uncoupled basal sodium absorption and chloride secretion in prairie dogs. Comp Biochem Physiol 100A (2):335-341, 1991.