Office 127
PA Biotechnology Center
3805 Old Easton Road
Doylestown, PA 18902

TEL: 215-589-6307
FAX: 215-489-4920

Alison.Evans@drexel.edu

Sc.D. 1991, Harvard School of Public Health, Boston, MA

Research Interests:

Prof. Evans earned her B.A. in Biological Sciences at the University of Chicago, and her Sc.D in Epidemiology at the Harvard School of Public Health. Her work prior to joining the Drexel School of Public Health includes positions as Statistical Consultant for the Harvard Community Health Plan in Boston, and Project Coordinator at the University of Chicago Medical Center. She is also currently an adjunct associate member of the Fox Chase Cancer Center in Philadelphia.

Past and current research projects for which Professor Evans is or has been Principal Investigator include "Epidemiology Studies of Hepatitis B Infection and its Complications" (Bristol-Myers Squibb Pharmaceutical Research Institute) and "Prevention of Liver Cancer in East Asian Populations in the Delaware Valley" (Pennsylvania Tobacco Settlement Health Research Formula Grant)

Selected peer-reviewed publications (in chronological order)

• Evans, A. A., Lefkopoulou, M., Mueller, N. E. Methods for inference on transmission in seroprevalence data for multiple infections. Am. J. Epidemiol. 135:1156-1165, 1992.
• London, W. T., Evans, A. A., McGlynn, K., Buetow, K., An, P., Gao, L-L., Lustbader, E., Ross, E., Chen, G-C., Shen, F-M. Viral, host and environmental risk factors for hepatocellular carcinoma: A prospective study in Haimen City, China. Intervirology 38:155-161, 1995.
• Evans, A. A., London, W. T. Interferon for chronic hepatitis B. Letter to the Editor. Ann. Intern. Med. 124:276, 1996.
• Evans, A. A., Fine, M. A., London, W. T. Spontaneous seroconversion in hepatitis B e antigen positive chronic hepatitis B: Implications for interferon therapy. J. Infect. Dis. 176:845-850, 1997.
• Zhou, T., Evans, A. A., London, W. T., Xia, X., Zou, H., Shen, F-M., Clapper, M. L. Glutathione S-transferase expression in HBV-associated human hepatocellular carcinogenesis. Cancer Res. 57:2749-2753, 1997.
• Evans, A. A., O’Connell, A. P., Pugh, J. C., Mason, W. S., Shen, F-M., Chen, G-C., Lin, W-Y., Dia, A., M’Boup, S., Dramé, B., London, W. T. Geographic variation in viral load among hepatitis B carriers with differing risks of hepatocellular carcinoma. Cancer Epidemiol. Biomarkers Prev. 7:559-565, 1998.
• Kruger, W. D., Evans, A. A., Wang, L., Malinow, M. R., Duell, P. B., Anderson, P. H., Block, P. C., Hess, D. L., Graf, E. E., Upson, B. Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Mol. Genet. Metab. 70:53-60, 2000.
• Dresler, C. M., Fratelli, C., Babb, J., Everley, L., Evans, A. A., Clapper, M. L. Gender differences in genetic susceptibility for lung cancer. Lung Cancer 30:153-160, 2000.
• Steel, L.F., Mattu, T.S., Mehta, A., Hebesteit, H., Dwek, R., Evans, A., London, W.T., Block, T. A proteomic approach for the discovery of early detection markers of hepatocellular carcinoma. Disease Markers 17:179-189, 2001.
• Malinow, M.R., Duell, P.B., Williams, M.A., Kruger, W.D., Evans, A.A., Anderson, P.H., Block, P.C., Hess, D.L., Upson, B.M., Graf, E.E., Irvin-Jones, A., Wang, L. Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations. Lipids 36:S27-S32, 2001.
• Evans, A. A., Chen, G., Ross, E. A., Shen, F. M., Lin, W. Y., London, W. T. Eight year follow-up of the 90,000 person Haimen City Cohort: I. Hepatocellular carcinoma mortality, risk factors, and gender differences. Cancer Epidemiol. Biomarkers Prev., 11:369-376, 2002.
• Evans, A. A., O'Connell, A. P., Mason, W. S., M'Boup, S., Shen, F-M, London, W. T.. Heterogeneity of the Pre-C/C Region of Hepatitis B Virus (HBV) in Chronic Carriers From China and West Africa. In: Viral Hepatitis and Liver Disease. Ed. H. Margolis et al, International Medical Press Ltd., London, pp. 365-367, 2002.
• Gao, L-L, Chen, G., Evans, A. A., Lin, W-Y, O’Connell, A. P., Propert, K. J., Williams, S., Shen, F-M, London, W. T., and the Haimen City Cooperating Group. Predicting hepatocellular carcinoma: A model developed from a 4-year prospective study of hepatitis B virus carriers. In: Viral Hepatitis and Liver Disease. Ed. H. Margolis et al, International Medical Press Ltd., London, pp. 416-420, 2002.
• Steel, L. F., Shumpert, D., Trotter, M., Seeholzer, S. H., Evans, A.A., London, W. T., Dwek, R., Block, T. M.. A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma. Proteomics 3:601-609, 2003.
• McGlynn, K.A., Hunter, K., LeVoyer T., Roush, J., Wise, P., Michielli, R. A., Shen, F-M, Evans, A.A., London, W.T., Buetow, K.H. Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans. Cancer Res. 63:4594-4601, 2003.
• Harris, R. A., Chen, G., Lin, W-Y, Shen, F-M, London, W. T., Evans, A. A. Spontaneous clearance of high-titer serum HBV DNA and risk of hepatocellular carcinoma in a Chinese population. Cancer Causes and Control 14:995-1000, 2003.
• Tang, B., Kruger, W.D., Chen, G., Shen, F-M, Lin, W-Y, Mboup, S., London, W.T., Evans, A.A. HBV viremia is associated with increased risk of HCC in chronic carriers. J. Med. Virol 72:35-40, 2004.
• Comunale, A.L., Mattu, T.S., Lowman, M.A., Evans, A.A., London, W.T., Semmes, O.J., Ward, M., Drake, R., Romano, P.R., Steel, L.F., Block, T.M., Mehta, A. Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. Proteomics 4:826-838, 2004.
• Block, T.M., Comunale, M.A., Lowman, M., Steel, L.F., Romano, P.R., Fimmel, C., Tennant, B.C., London, W.T., Evans, A.A., Blumberg, B.S., Dwek, R.A., Mattu, T.S., Mehta, A.S. Use of targeted glycoproteomics to identify serum glcyoproteins that correlate with liver cancer in woodchucks and humans. PNAS 102:779-784, 2005.
• Chen, G., Lin, W-Y, Shen, F-M, Iloeje, U.H., London, W.T., Evans, A.A. Chronic hepatitis B virus infection and mortality from non-liver causes: results from the Haimen City cohort study. Int. J. Epidemiol. 34:132-137, 2005.
• Sakoda, L.C., Graubard, B.I., Evans, A.A., London, W.T., Lin, W-Y, Shen, F-M, McGlynn, K.A. Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China. Int. J. Cancer 115:618-624, 2005.
• Kelloff, G. J., Lippman, S. M., Dannenberg, A.J., Sigman, C. C. Pearce, H. L, Szabo, E. Jordan, V. C., Spitz, M. R., Mills, G. B., Papadimitrakopoulou, V. A., Lotan, R., Aggarwal, B. B., Bresalier, R. S., Kim, J., Arun, B., Lu, K. H., Thomas, M. E., Rhodes, H. E., Brewer, M. A., Follen, M., Shin, D. M., Parnes, H. L., Evans, A. A., Blot, W. J., Chow, W-H, Blount, P. L., Maley, C. C., Wang, K. K., Lee, J. J., Dubinett, S. M., Engstrom, P. F., Meyskens Jr., F. L., Ransohoff, D. R., Hawk, E. T., Levin, B., Nelson, W. G., Hong, W. K. The promise of molecular biomarkers for cancer prevention and treatment and prevention of intraepithelial neoplasia (IEN): A Plan to Move Forward (AACR Cancer Prevention Task Force). Clinical Cancer Research, 12:3661-97, 2006.
• Chen G., Lin W-Y, Shen F, Iloeje U. H., London W. T., Evans, A. A. Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study. In press, American Journal of Gastroenterology, 101:1797-1803, 2006.

This website is maintained by: Hoi.Cheung@drexel.edu.