Dr. Lippa directs the Dementia Neurology Research Laboratory at Drexel University College of Medicine, investigating the question of why people develop memory loss/forgetfulness, dementia, and other cognitive problems. Her basic science laboratory research addresses the clinicopathologic mechanisms underlying neuronal death in neurodegenerative diseases. Most of her work is focused on characterizing abnormal proteins in Alzheimer's disease and related types of dementia, including Pick's disease and Lewy body disease.
As neuropathologist and director of Drexel University College of Medicine's Neurology Brain, Blood and Cerebrospinal Fluid Bank, Dr. Lippa has one of the country's largest collections of brain tissue, blood, and cerebrospinal fluid from patients with genetic forms of degenerative diseases.
Much of her work is collaborative; she partners with biochemists, geneticists, pathologists and other physicians from within Drexel University College of Medicine and around the world. Dr. Lippa has a reputation for organizing networks of individuals to work collaboratively to answer scientific questions about these diseases. The long-term goal of her work is to understand the underlying mechanisms in degenerative brain diseases and develop rational therapies to prevent these diseases or slow their progression.
Selected Publications:
"Compensating for Alzheimer's Lesions: Evidence that Size Counts"
C.F. Lippa
Neurology (2009)
"Cerebrospinal immunoglobulin level changes and clinical response to treatment of Hashimoto's encephalopathy"
G. Gliebus and C.F. Lippa
Am J Alzheimer's Dis Other Demen (2009)
"Levetiracetam: A practical option for seizure management in elderly patients with cognitive impairment"
C.F. Lippa, A. Rosso, M. Hepler, S. Jenssen, J. Pillai, D. Irwin
Am J Alzheimer's Dis Other Demen (2009)
"Dementia with Lewy bodies and Parkinson's disease dementia may be best viewed as two distinct entities"
G.J. Revuelta, C.F. Lippa
Int Psychogeriatr 28:2-5 (2009)
"Progranulin expression in ALS"
D. Irwin, C.F. Lippa, A. Rosso
J Neurol Sci, 276(1-2):9-13 (2009)
"Clinical improvement of limb dystonia in corticobasal degeneration following a five-day lidocaine infusion: a case report"
D. Irwin, G. Revuelta, C.F. Lippa
J Neurol Sci 15;277(1-2):164-6 (2009)
"Association between progranulin and β-amyloid in dementia with Lewy bodies"
G.J. Revuelta, A. Rosso, C.F. Lippa
Am J Alzheimer's Dis Other Demen, 23(5):488-93 (2009)
"Caffeine – neuroprotective functions in cognition and Alzheimer's disease"
A. Rosso, J. Mossey, C.F. Lippa
Am J Alzheimers Dis Other Demen, 23:417-422 (2008)
"Novel Mutations in TARDBP (TDP-43) in Familial Patients with Amyotrophic Lateral Sclerosis"
N.J. Rutherford, M.C. Baker, Y.J. Zhang, J.M. Gass, H. Stewart, B. Kelley, K. Kuntz, N. Finch, R.J.P. Crook, E. Sorenson, C.F. Lippa, E. Bigio, T.G. Beach, D.H. Geschwind, D. Knopman, H. Mitsumoto, R. Petersen, N. Cashman, M. Hutton, B. Boeve, N. Graff-Radford, Z.K. Wzsolek, R.J. Caselli, D. Dickson, I.R. Mackenzie, L. Petrucelli, R. Rademakers
PLoS Genet, 4(9) (2008)
"Neuritic pathology as a correlate of synaptic loss in dementia with Lewy bodies"
G.J. Revuelta, A. Rosso, C.F. Lippa
Am J Alzheimers Dis Other Demen, 23:97-102 (2008)
"Dementia: Many roads but not built in a day"
C.F. Lippa and D.S. Knopman
Neurology 68:2193-2194 (2007)
"An international initiative to study Phenotypic variability associated with progranulin haploinsufficiency in patients with the common c.1477C>T (p.R493X) mutation"
R. Rademakers, M. Baker, J. Gass, J. Adamson, E. Huey, P. Momen, S. Spina, G. Coppola, A. Karydas, H. Stewart, N. Johnson, G.Y. Hsiung, K. Kuntz, E. Steinbart, E. McCarty Wood, K. Josephs, E. Sorenson, K. Womack, S.M. Pickering-Brown, V.Y. Lee, P. Schofield, B. Ghetti, J.D. Schellenberg, T.D. Beach, M. Mesulam, J. Grafman, I. Mackenzie, H. Feldman, T. Bird, R. Petersen, D. Knopman, B. Boeve, D. Geschwind, B. Miller, Z. Wzsolek, C.F. Lippa, E. Bigio, D. Dickson, N. Graff-Radford and M. Hutton
Lancet Neurology 6:857-68 (2007)
"Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees"
W.E. Klunk, J.C. Price, C.A. Mathis, N.D. Tsopelas, B.J. Lopresti, S. Ziolko, W. Bi, M.D. Ikonomovic, J. Saxton, E. Snitz, D.A. Pollen, M. Moonis, C.F. Lippa, J. Swearer, K. Johnson, H. Aizenstein, S.T. DeKosky
J Neurosci 27(23); 6174-6184 (2007)
"Cognition and ALS"
D. Irwins, C.F. Lippa, J.M. Swearer
Am J Alzheimers Dis Other Demen, 22:300-312 (2007)
"DLB and PDD Boundary Issues: Diagnosis, Treatment, Molecular Pathology, and Biomarkers"
C.F. Lippa, J.E. Duda, M. Grossman, H.I. Hurtig, D. Aarsland, B.F. Boeve, D.J. Brooks, D.W. Dickson, B. Dubois, M. Emre, S. Fahn, J.M. Farmer, D. Galasko, J.E. Galvin, C.G. Goetz, J.H. Growdon, K.A. Gwinn-Hardy, J. Hardy, P. Heutink, T. Iwatsubo, K. Kosaka, V.M. Lee, J.B. Leverenz, E. Masliah, I.G. McKeith, R.L. Nussbaum, C.W. Olanow, B.M. Ravina, A.B. Singleton, C.M. Tanner, J.Q. Trojanowski, Z.K. Wszolek
Neurology 68:812-819 (2007)
"Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins"
K. Haleem, C.F. Lippa, T.W. Smith, H. Kowa, J. Wu, T. Abdelhak, T. Iwatsubo
Am J Alzheimers Dis Other Demen 22(2): 137-144 (2007)
"The influence of beta-blockers on delayed memory function in people with cognitive impairment"
G. Gliebus, C.F. Lippa
Am J Alzheimers Dis Other Demen 22: 57-61 (2007)
"CPC: A 75-year-old man with cognitive impairment and gait changes"
C.F. Lippa, B.F. Boeve, J.E. Parisi, M.B. Keegan
Neurology 69:1183-1189 (2007)
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