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Christos D. Katsetos, MD, PhD, FRCPath

Attending Neuropathologist; Research Professor of Pediatrics and Neurology; Professor of Pathology

  • Department:Pediatrics
  • Specialty:Neuropathology
  • Education: MD, St. George's University School of Medicine, Grenada, West Indies (1983); PhD, Neuropathology, The Gade Institute, University of Bergen, Norway (2002)
Patient Care

Journal of Cellular Physiology Dr. Christos D. Katsetos specializes in general and pediatric neuropathology and neuromuscular (muscle and nerve) pathology. Areas of clinical interest include brain tumors, cerebrovascular and immune-mediated diseases of the central nervous system (CNS), inflammatory myopathies, and neuropathologic correlates of neurocognitive disorders. He is attending neuropathologist at Hahnemann University Hospital and St. Christopher's Hospital for Children in Philadelphia, PA.

Clinical/Medical Staff Appointments

  • Attending Neuropathologist, Hahnemann University Hospital, Philadelphia, PA (2008-present)
  • Neuropathologist, Section of Neurology and Department of Pathology & Laboratory Medicine, St. Christopher’s Hospital for Children, Philadelphia, PA (1998-present)
  • Director of Neuropathology, Hahnemann University, Philadelphia, PA (1991-94)

Selected Honors & Awards

  • Editorial Board, Journal of Neuropathology and Experimental Neurology (2007-present)
  • Established Investigator Award, St. Christopher’s Foundation for Children (2004-2009)
  • Promoted to Fellowship of the Royal College of Pathologists (FRCPath) (2006)
  • Member of the Royal College of Pathologists (MRCPath) by Published Works (2000)
  • Honorary Plaque for Professional Achievements in Pathology Research, Department of Pathology, University of Ioannina, Medical School, Greece (1996)

Journal of Neuropathology and Experimental Neurology Medical Licensure

  • License without restriction, Commonwealth of Pennsylvania
  • License without restriction, New York State

Membership in Professional Societies

  • Member, American Association of Neuropathologists
  • Fellow, Royal College of Pathologists, UK
  • Member, British Neuropathological Society, UK
  • Member, International Society of Neuropathology
Research

Dr. Katsetos is a clinical and research neuropathologist with over 25 years of experience in translational and experimental studies in human neurological diseases and related animal and in vitro models. During the past two decades his research has been directed at the phenotypic characterization of neuronal and glial precursor cells and the elucidation of cellular and molecular mechanisms underlying the pathogenesis of neurological diseases including brain tumors, perinatal hypoxic/ischemic brain injury, and immune-mediated CNS pathology in the context of demyelinating disease. Currently, his investigative work focuses on the role of the microtubule cytoskeleton in cancer with emphasis on brain tumors (gliomas). It also deals with the functional interconnections between the cytoskeleton, calcium homeostasis, oxidative stress, and mitochondrial function in neurological and neuromuscular diseases.

Publications

Selected Publications (See all Dr. Katsetos' publications in PubMed, "Katsetos CD".)

"Mitochondrial dysfunction in gliomas."
Katsetos, C.D., Anni, H., and Dráber P.
Seminars in Pediatric Neurology 20: 216-227 (2013) 

"Mitochondrial dysfunction in neuromuscular disorders."
Katsetos, C.D., Koutzaki, S., and Melvin, J.J.
Seminars in Pediatric Neurology 20: 202-215 (2013)

"Tubulins as therapeutic targets in cancer: from bench to bedside."
Katsetos, C.D. and Dráber, P.
Current Pharmaceutical Design, 18(19):2778-2792 (2012)

"Overexpression of gamma-tubulin in non-small cell lung cancer."
Maounis, N.F., Dráberová, E., Mahera, E., Chorti, M., Caracciolo, V. , Sulimenko, T., Riga, D., Trakas, N., Emmanouilidou, A., Giordano, A., Dráber, P., and Katsetos, C.D.
Histology and Histopathology 27:1183-119 (2012)

"Nuclear gamma-tubulin associates with nucleoli and interacts with tumor suppressor protein C53."
Horejší, B., Vinopal, S., Sládková, V., Dráberová, E., Sulimenko, V., Sulimenko, T., Vosecká, V., Philimonenko, A., Hozák, P., Katsetos, C.D., and Dráber, P.
Journal of Cellular Physiology, 227(1):367-382 (2012) doi: 10.1002/jcp.22772

"Microtubule severing ATPase spastin in glioblastoma multiforme: Increased expression in human glioblastoma cell lines and roles in cell motility and proliferation."
Dráberová, E., Vinopal, S., Morfini, G., Liu, P.S., Sládková, V., Sulimenko, T., Burns, M.R., Solowska, J., Kulandeival, K., de Chadarevian, J.-P., Legido, A., Mörk, S.J., Jurácek, J., Baas, P.W., Dráber, P., and Katsetos, C.D.
Journal of Neuropathology & Experimental Neurology, 70(9): 811-826 (2011)

"Targeting betaIII-tubulin in glioblastoma multiforme: From cell biology and histopathology to cancer therapeutics."
Katsetos, C.D., Dráber, P., and Kavallaris, M.
Anti-Cancer Agents in Medicinal Chemistry, 11(8):719-728 (2011)

"Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines."
Caracciolo, V., D'Agostino, L., Dráberová, E., Sladková, V., Crozier-Fitzgerald, C., Agamanolis, D.P., de Chadarévian, J.-P., Legido, A., Giordano, A., Dráber, P., and Katsetos, C.D.
Journal of Cellular Physiology, 223:519-529 (2010)

"Tubulin targets in the pathobiology and treatment of glioblastoma multiforme. I. Class III beta tubulin isotype."
Katsetos, C.D., Dráberová, E., Legido, A., Dumontet, C., and Dráber, P.
Journal of Cellular Physiology, 221:505-513 (2009)

"Tubulin targets in the pathobiology and treatment of glioblastoma multiforme. II. gamma-Tubulin."
Katsetos, C.D., Dráberová, E., Legido, A., and Dráber, P.
Journal of Cellular Physiology, 221:514-520 (2009)

"Class III beta-tubulin is constitutively co-expressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: Implications for phenotypic identity."
Dráberová, E., Del Valle, L., Gordon, J., Marková, V., Smejkalová, B., Bertrand,   L,, de Chadarévian, J.-P., Agamanolis, D.P., Legido, A., Khalili, K., Dráber, P., and Katsetos, C.D.
Journal of Neuropathology & Experimental Neurology, 67: 341-354 (2008)

"Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells."
Katsetos, C.D., Dráberová, E., Smejkalová, B., Reddy, G., Bertrand, L., de Chadarévian, J.-P., Legido, A., Nissanov, J., Baas, P.W., and Dráber, P.
Neurochemical Research 32:1387-1398 (2007)

"Altered cellular distribution and subcellular sorting of gamma-tubulin in astrocytic gliomas and human glioblastoma cell lines."
Katsetos, C.D., Reddy, G., Dráberová, E., Smejkalova, B., Del Valle, L., Ashraf, Q., Tadevosyan,  A., Yelin, K., Maraziotis, T., Mishra, O.P., Nissanov, J., Mörk, S., Legido, A., Baas, P.W., de Chadarévian, J.-P., and Dráber, P.
Journal of Neuropathology & Experimental Neurology, 65:465-477 (2006)

"Class III beta-tubulin in human development and cancer."
Katsetos, C.D., Herman, M.M., and Mörk, S.J.
Cell Motility and the Cytoskeleton, 55:77-96 (2003)

"Class III beta-tubulin isotype: A key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology."
Katsetos, C.D., Legido, A., Perentes, E., and Mörk, S.J.
Journal of Child Neurology, 18:851-866 (2003)

"On the neuronal/neuroblastic nature of medulloblastomas: A tribute to Pio del Rio Hortega and Moises Polak."
Katsetos, C.D., Del Valle, L, Legido, A., de Chadarevian, J.-P., Perentes, E., and Mörk, S.J.
Acta Neuropathologica (Berlin) 105:1-13 (2003)

"Localization of neuronal class III beta-tubulin in oligodendrogliomas. Comparison with Ki-67 proliferative index and 1p/19q status."
Katsetos, C.D., Del Valle, L.,  Geddes, J.F., Aldape, K., Boyd, J.C., Legido, A.,  Khalili, K., Perentes, E., and Mörk, S.J.
Journal of Neuropathology & Experimental Neurology, 61:307-320 (2002)

"Aberrant localization of the neuronal class III beta-tubulin in astrocytomas: A marker for anaplastic potential."
Katsetos, C.D., Del Valle, L., Geddes, J.F., Assimakopoulou, M., Legido, A., Boyd, J.C.,  Balin, B.J., Parikh, N.A., de Chadarevian, J.-P., Maraziotis, T., Varakis, J.N., Matsas, R., Spano, A., Frankfurter, A., Herman, M.M., and Khalili, K.
Archives of Pathology & Laboratory Medicine, 125: 613-624 (2001)

"Differential distribution of the neuron-associated class III beta-tubulin in neuroendocrine lung tumors."
Katsetos, C.D., Kontogeorgos, G., Geddes, J.F., Herman, M.M., Tsimara-Papastamatiou, H., Yu, Y., Sakkas, L.I., Tsokos, M., Patchefsky, A.S., Ehya, H., Cooper, H.S., Provencio, J., Spano, A.J., and Frankfurter, A.
Archives of Pathology & Laboratory Medicine, 124:535-544 (2000)

"Class III beta-tubulin isotype (beta III) in the adrenal medulla: III. Differential expression of neuronal and glial antigens identifies two distinct populations of neuronal and glial-like (sustentacular) cells in the PC12 rat pheochromocytoma cell line maintained in a Gelfoam matrix system."
Katsetos, C.D., Herman, M.M., Balin, B.J., Vinores, S.A., Hessler, R.B., Arking, E.J., Karkavelas, G., and Frankfurter A.
The Anatomical Record, 250:351-365 (1998)

"Class III beta-tubulin isotype (beta III) in the adrenal medulla: I. Localization in the developing human adrenal medulla."
Katsetos, C.D., Karkavelas, G., Herman, M.M., Vinores, S.A., Provencio, J., Spano, A.J., and Frankfurter A.
The Anatomical Record, 250:335-343 (1998)

"Differential localization of class III, beta-tubulin isotype and calbindin-D28k defines distinct neuronal types in the developing human cerebellar cortex."
Katsetos, C.D., Frankfurter, A., Christakos, S., Mancall, E.L., Vlachos, I., and Urich, H.
Journal of Neuropathology & Experimental Neurology, 52:655-666 (1993)

Teaching

Dr. Katsetos is involved in Neuropathology teaching of Residents in Pathology & Laboratory Medicine and Neurology, Fellows in Pediatric Pathology and Child Neurology, and Medical Students. He is also Member of the Graduate Program in Neurosciences (Cellular Neurosciences).

Current Academic Appointments

  • Professor, Department of Pathology & Laboratory Medicine, Drexel University College  of Medicine, Philadelphia, PA (2008-present)
  • Research Professor, Department of Neurology, Drexel University College of Medicine (secondary appointment) (2007-present)
  • Member, Graduate Program in Neuroscience, Drexel University College of Medicine (2006-present)
  • Research Professor, Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (2003-present)
  • Co-director, Neurology Research, St. Christopher's Hospital for Children, Philadelphia, PA (1998-present)

Previous Academic Appointments

  • Research Professor, Department of Pathology & Laboratory Medicine, Drexel University College of Medicine, Philadelphia, PA (2006-2008)
  • Research Associate Professor, Department of Pediatrics, MCP Hahnemann University, Philadelphia, PA (1998-2003)
  • Research Assistant Professor, Department of Microbiology & Immunology, Temple University School of Medicine, Philadelphia, PA (1996-98)
  • Assistant Professor, Department of Pathology & Laboratory Medicine, Medical College of Pennsylvania and Hahnemann University, Philadelphia, PA (1994-95)
  • Assistant Professor, Departments of Pathology & Laboratory Medicine, Neurology and Neurosurgery, Hahnemann University, Philadelphia, PA (1990-94)
Specialties
  • Neuropathology
Services and Clinical Interests
  • Brain tumors
  • Cerebrovascular diseases in children
  • Immune-mediated diseases of the CNS
  • Inflammatory myopathies
  • Muscle and nerve pathology
  • Neurocognitive disorders, neuropathologic correlates
  • Neuropathology (autopsy and surgical)
  • Prenatal & perinatal hypoxic/ischemic CNS damage
Residency
  • Resident in Anatomic Pathology, Shadyside Hospital, Pittsburgh, Pa. (1983-1985)
Fellowship
  • Fellow in Anatomic Pathology, Beth Israel Medical Center, New York, N.Y. (1989-90)
  • Fellow in Neuropathology, University of Virginia Hospitals, Charlottesville, Va. (1987-89)
  • Fellow in Neuropathology, Brown University at Rhode Island Hospital and The Miriam Hospital, Providence, R.I. (1985-87)

St. Christopher's Hospital for Children is a primary academic campus of Drexel University College of Medicine. Its physicians are non-compensated members of the teaching faculty of Drexel University College of Medicine and its clinical practices are independent of Drexel University College of Medicine.

Practice Locations

St. Christopher's Hospital for Children, Section of Neurology
3601 A Street
Philadelphia, PA 19134
Phone: 215-427-5273
Fax: 215-427-4284

Department of Pathology and Laboratory Medicine
245 N. 15th Street
MS 435
Philadelphia, PA 19102
Phone: 215-762-8941
Fax: 215-762-3274

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