 M.D. (1983) St. George’s University School of Medicine, Grenada, West Indies
Dr.philos. (Ph.D.) Neuropathology (2002) The Gade Institute, University of Bergen, Norway
http://www.uib.no/info/dr_grad/2002/katstetos.htm
Specialty Area
Neuropathology (Clinical/Diagnostic)
Experimental Neuropathology, Cell Biology of Microtubules (Research)
Postgraduate Training
Resident in Anatomic Pathology (1983-85), Shadyside Hospital, Pittsburgh, Pennsylvania
Fellow in Neuropathology (1985-87), Brown University at Rhode Island Hospital and The Miriam Hospital, Providence, Rhode Island
Fellow in Neuropathology (1987-89), University of Virginia Hospitals, Charlottesville, Virginia
Fellow in Anatomic Pathology (1989-90), Beth Israel Medical Center, New York, NY
Academic Appointments
Assistant Professor, Departments of Pathology & Laboratory Medicine, Neurology and Neurosurgery (1990-94), Hahnemann University, Philadelphia, Pennsylvania
Assistant Professor, Department of Pathology & Laboratory Medicine (1994-95), Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania
Research Assistant Professor, Department of Microbiology & Immunology (1996-98), Temple University School of Medicine, Philadelphia, Pennsylvania
Co-director, Neurology Research Laboratory (1998-present), St. Christopher’s Hospital for Children, Philadelphia, Pennsylvania
Research Associate Professor, Department of Pediatrics (1998-2003), MCP Hahnemann University, Philadelphia, Pennsylvania
Research Professor, Department of Pediatrics (2003-present), Drexel University College of Medicine, Philadelphia, Pennsylvania
Research Professor, Department of Pathology & Laboratory Medicine (2006), Drexel University College of Medicine, Philadelphia, Pennsylvania (joint appointment)
Member, Graduate Program in Neuroscience (2006), Drexel University College of Medicine
Research Professor, Department of Neurology (2007-present), Drexel University College of Medicine
(secondary appointment)
Professor, Department of Pathology & Laboratory Medicine (2008-present), Drexel University College of Medicine, Philadelphia, Pennsylvania
Clinical/Medical Staff Appointments
Director of Neuropathology (1991-94), Hahnemann University, Philadelphia, Pennsylvania
Neuropathologist (1998-present), Section of Neurology and Department of Pathology & Laboratory Medicine,
St. Christopher’s Hospital for Children, Philadelphia, Pennsylvania http://www.stchristophershospital.com/find-a-physician/120.
Attending Neuropathologist (2008-present), Hahnemann University Hospital, Philadelphia, Pennsylvania
Medical Licensure
License without restriction, Commonwealth of Pennsylvania
License without restriction, New York State
Clinical/Diagnostic Interests
Brain tumors, perinatal hypoxic-ischemic encephalopathy, cerebrovascular disease, demyelinating and immune-mediated diseases of the CNS, autopsy neuropathology and muscle & nerve pathology.
Selected Honors & Awards
Honorary Plaque for Professional Achievements in Pathology Research (1996), Department of Pathology, University of Ioannina, Medical School, Greece
Member of the Royal College of Pathologists (MRCPath) by Published Works (2000)
Promoted to Fellowship of the Royal College of Pathologists (FRCPath) (2006)
Established Investigator Award (2004-2009), St. Christopher’s Foundation for Children
Editorial Board, Journal of Neuropathology and Experimental Neurology (2007-2010)
Membership in Professional Societies
Member, American Association of Neuropathologists
Member, American Society for Investigative Pathology
Member, Federation of American Societies for Experimental Biology
Fellow, Royal College of Pathologists, UK
Member, British Neuropathological Society, UK
Member, International Society of Neuropathology
Research
During the past two decades, my research has focused on cellular aspects of growth and differentiation of human embryonal tumors of the nervous system (medulloblastomas, neuroblastomas and retinoblastomas) and on molecular aspects of viral neuro-oncogenesis. Currently, my research focuses primarily on alterations of the microtubule cytoskeleton in human brain tumors with emphasis on glioblastomas.
Selected publications
Caracciolo, V., D’Agostino, L., Dráberová, E., Sladková, V., Crozier-Fitzgerald, C., Agamanolis D.P., de Chadarévian, J.-P., Legido, A., Giordano, A., Dráber, P., Katsetos, C.D. Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines. J. Cell. Physiol. (In press)
Katsetos, C.D., Dráberová, E., Legido, A., Dumontet, C., Dráber, P. (2009) Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. Class III beta tubulin isotype. J. Cell. Physiol.
Katsetos, C.D., Dráberová, E., Legido, A., Dráber, P. (2009) Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-Tubulin. J. Cell. Physiol.
Dráberová, E., Del Valle, L., Gordon, J., Marková, V., Smejkalová, B., Bertrand, L,, de Chadarévian, J.-P., Agamanolis, D.P., Legido, A., Khalili, K., Dráber, P., Katsetos, C.D. (2008) Class III beta-tubulin is constitutively co-expressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: Implications for phenotypic identity. J. Neuropathol. Exp. Neurol. 67: 341-354.
Katsetos, C.D., Dráberová, E., Smejkalová, B., Reddy, G., Bertrand, L., de Chadarévian, J.-P., Legido, A., Nissanov, J., Baas, P.W., Dráber, P. (2007) Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. Neurochem. Res. 32:1387-1398.
Katsetos, C.D., Reddy, G., Dráberová, E., Smejkalova, B., Del Valle, L., Ashraf, Q., Tadevosyan, A., Yelin, K., Maraziotis, T., Mishra, O.P., Nissanov, J., Mörk, S., Legido, A., Baas, P.W., de Chadarévian, J.-P., Dráber, P. (2006) Altered cellular distribution and subcellular sorting of gamma-tubulin in astrocytic gliomas and human glioblastoma cell lines. J. Neuropathol. Exp. Neurol. 65:465-477.
Katsetos, C.D., Herman, M.M., Mörk, S.J. (2003) Class III beta-tubulin in human development and cancer. Cell Motil. Cytoskeleton 55:77-96.
Katsetos, C.D., Legido, A., Perentes, E., Mörk, S.J. (2003) Class III beta-tubulin isotype: A key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology. J. Child Neurol. 18:851-866.
Katsetos, C.D., Del Valle, L, Legido, A., de Chadarevian, J.-P., Perentes, E., Mörk, S.J. (2003) On the neuronal/neuroblastic nature of medulloblastomas: A tribute to Pio del Rio Hortega and Moises Polak. Acta Neuropathol. (Berl.) 105:1-13.
Katsetos, C.D., Del Valle, L., Geddes, J.F., Aldape, K., Boyd, J.C., Legido, A., Khalili, K., Perentes, E., Mörk, S.J. (2002) Localization of neuronal class III beta-tubulin in oligodendrogliomas. Comparison with Ki-67 proliferative index and 1p/19q status. J. Neuropathol. Exp. Neurol. 61:307-320.
Katsetos, C.D., Del Valle, L., Geddes, J.F., Assimakopoulou, M., Legido, A., Boyd, J.C., Balin, B.J., Parikh, N.A., de Chadarevian, J.-P., Maraziotis, T., Varakis, J.N., Matsas, R., Spano, A., Frankfurter, A., Herman, M.M., Khalili, K. (2001) Aberrant localization of the neuronal class III beta-tubulin in astrocytomas: A marker for anaplastic potential. Arch. Pathol. Lab. Med. 125: 613-624.
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