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Itzhak Fischer, PhD

Professor and Chair

  • Department:Neurobiology and Anatomy
  • Education: MS in Computer Science - University of California, Irvine (1983); PhD in Molecular Biology and Biochemistry - University of California (1981); MS in Biology - Israel Institute of Technology (1976); BS in Chemistry - Israel Institute of Technology (1970)
Research Overview

Research interests: Our goal is to promote regeneration and recovery of function after spinal cord injury by identifying the best strategies for cellular transplantation and to apply gene therapy methods to introduce therapeutic genes into the injured spinal cord. We are currently studying the efficacy of genetically modified fibroblasts, multipotential neural stem cells, neural and glial precursors, and bone marrow stromal cells.

Research

Gene Therapy / Genetically Modified Fibroblasts
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Gene Therapy / Genetically Modified Fibroblasts

We use retrovirus and lentivirus vectors to genetically modify cells (ex vivo gene therapy) and deliver neurotrophin genes as a strategy of promoting survival of injured neurons and axon regeneration. We have modified fibroblasts using a retrovirus containing neurotrophic genes neurotrophin-3 (NT-3) or brain derived neurotrophic factor (BDNF) and a marker gene, allowing us to track genetically modified cells via various staining methods. We also use lentivirus for in vivo gene therapy by direct injection of high titer virus into the spinal cord, creating neurotrophin gradients to promote axon growth.


Neural Stem Cells and Progenitors
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Neural Stem Cells and Progenitors

We study the properties of multipotential neural stem cells as well as neuronal restricted precursors (NRP) and glial restricted precursors (GRP) and test their therapeutic potential following grafting into the injured adult spinal cord. We found  that, in contrast to neural stem cells, transplants of lineage restricted precursors survive and differentiate in the adult CNS into the appropriate phenotypes and generate a microenvironment that allow formation of neurons even in the injured spinal cord. Our transplantation experiments address fundamental issues of the potential and fate as well as the development of therapeutic strategies for cell replacement the repair of spinal cord injury. Our current projects test the ability of neural precursors to form functional connections in a model of dorsal column lesion and repair a neuronal circuit in the lumbar spinal cord.


Bone Marrow Stromal Cells
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Bone Marrow Stromal Cells

The use of human marrow stromal cells (MSC), an adult stem cell, is promising because MSCs can be obtained from the bone marrow of spinal cord injury patients. Our grafting experiments of adult stem cells into the injured spinal cord demonstrated that they provide protection from secondary injury and produce a permissive environment for growing axons by secretion of therapeutic factors Our studies are focused on developing clinically relevant protocols that allow delivery of cells by minimally invasive methods (lumbar puncture) and detection of grafted cells by non-invasive imaging (MRI).


Structure and Function of the Neuronal Cytoskeleton
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Structure and Function of the Neuronal Cytoskeleton

We have studied the expression and function of cytoskeleton proteins, particularly microtubule proteins in the nervous system during development and regeneration in both the PNS and CNS. We used biochemical, cellular, and molecular approaches that include inhibition by antisense oligonucleotides, microinjection of recombinant antibodies, analysis of transcriptional regulation and transgenic animal. We study the role of MAP1B and tau in axonal growth and the mechanism of their phosphorylation and possible application of these genes to improve regeneration. These projects continue mostly through collaborations.

Publications

Neural Stem Cells

"Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration."
Haas C, Neuhuber B, Yamagami T, Rao M, Fischer I
Experimental Neurol. 233(2):717-32, 2012.

"Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord."
Bonner JF, Connors TM, Silverman WF, Kowalski DP, Lemay MA, and Fischer I
J Neuroscience. 31:4675-4686. PMID: 21430166, 2011.

"Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter, GLT1, following traumatic spinal cord injury."
Lepore AC, O’Donnell, J, Bonner JF, Courtney P, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ.
The Journal of Neuroscience Research. 89(7):1001-17. PMID: 21488085, 2011.

"Transplantation of human glial restricted progenitors and astrocytes into spinal cord contusion."
Jin Y, Neuhuber B, Singh A, Bouyer J, Bonner J, Himes BT, Campanelli JT, Fischer I
J. Neurotrauma. 28(4):579-94. PMCID:PMC3070147, 2011.

"Neuriteoutgrowth of neural progenitors in presence of inhibitory proteoglycans."
See J., M. Neuhuber B, Bonner, and I. Fischer
Journal of Neurotrauma 27(5):951-57. PMID:20102265, 2010.

"Promoting directional axon growth from neural progenitors grafted into the injured spinal cord."
Bonner JF, Blesch A, Neuhuber B, Fischer I
Journal of Neuroscience Research 88(6):1182-92. PMCID: PMC2844860, 2009.

"Stem cell delivery by lumbar puncture is a suitable alternative to cell delivery by direct injection"
Neuhuber B, Barshinger AL, Paul C, Shumsky J , Mitsui T, Fischer I
J. Neurosurgery: Spine 9:390-399, 2008.

"Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury."
Park KI, Himes BT, Stieg PE, Tessler A, Fischer I, Snyder EY
Exp. Neurol. 199(1):179-190, 2006.

"Neurogenesis in Talpha-1 tubulin transgenic mice during development and after injury."
Coksaygan T, Magnus T, Cai J, Mughal M, Lepore A, Xue H, Fischer I, Rao MS.
Exp Neurol.197:475-85, 2006.

"Long-term fate of neural precursor cells following transplantation into developing and adult CNS"
Lepore AC, Neuhuber B, Connors TM, Han SS, Liu Y, Daniels MP, Rao MS, Fischer I
Neuroscience 142(1):287-304, 2006.

"MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord"
Lepore AC, Walczak P, Rao MS, Fischer I, Bulte JW
Exp. Neurol. 201(1):49-59, 2006.

"Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord"
Lepore A, Bakshi A, Swanger SA, Rao MS, Fischer I
Brain Research 1045:206-216, 2005.

"Lineage-restricted neural precursors survive, migrate and differentiate following transplantation into the injured adult spinal cord"
Lepore A, Fischer I
Experimental Neurology 194:230-242, 2005.

"Fate of immortalized human neuronal progenitor cells transplanted into rat spinal cord"
Li P, Tessler A, Han SSW, Fischer I, Rao MS, Selzer M
Arch. Neurol. 62(2):223-9, 2005.

"Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity, and modifies intraspinal circuitry"
Mitsui T, Shumsky JS, Lepore A, Murray M, Fischer I
J. Neuroscience 25(42):9624-36, 2005.

"Transplantation of glial-restricted precursor cells into the adult spinal cord: Survival, glial-specific differentiation, and preferential migration in white matter"
Han SS, Liu Y, Tyler-Polsz C, Rao MS, Fischer I
Glia 45:1-16, 2004.

"Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS"
Lepore AC, Han SSW, Tyler-Polsz CJ, Cai J, Rao MS, Fischer I
Neuron Glia Biology 1:113-126, 2004.

"CD44 expression identifies astrocyte-restricted precursor cells"
Liu Y, Han SSW, Wu Y, Tuohy TMF, Xue H, Cai J, Back SA, Sherman LS, Fischer I, Rao MS
Develop. Biol. 276:31-46, 2004.

"Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord"
Han SS, Kang DY, Mujtaba T, Rao MS, Fischer I
Exp. Neurol. 177:360-375, 2002.

"Stable expression of the alkaline phosphatase marker gene by neural cells in culture and after transplantation into the CNS using cells derived from a transgenic rat"
Mujtaba T, Han SS, Fischer I, Sandgren EP, Rao MS.
Exp. Neurol. 174:48-57, 2002.

"Isolation of a glial-restricted tripotential cell line from embryonic spinal cord cultures"
Wu YY, Mujtaba T, Han SSW, Fischer I, Rao MS
Glia 38:65-79, 2002.

"Radial glial cell line C6-R integrates preferentially in adult white matter and facilitates migration of co-implanted neurons in vivo"
Hormigo A, McCarthy M, Nothias JM, Hasegawa K, Huang W, Friendlander DR, Fischer I, Fishell G, Grumet M
Exp. Neurol. 168:310-322, 2001.

"Characterization and intraspinal grafting of EGF/bFGF-dependent neurospheres derived from embryonic rat spinal cord"
Chow SY, Moul J, Tobias C, Himes BT, Liu Y, Obrocka M, Hodge L, Tessler A, Fischer I
Brain Res. 874:87-106, 2000.

"Neural stem cells and gene therapy: Prospects for repairing the injured spinal cord"
Han S, Fischer I
JAMA 293:2300-2301, 2000.

Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus"
Liu Y, Himes T, Solowska-Baird J, Moul J, Chow S, Tessler A, Snyder E, Fischer I
Experimental Neurology 158:9-26, 1999.

"Role of vimentin in early stages of neuritogenesis in cultured hippocampal neurons"
Boyne LJ, Fischer I, Shea TB
Int. J. Dev. Neurosci. 14(6):739-48, 1996.

Bone Marrow Stromal Cells

“Intrathecal delivery of stem cells to the spinal cord.”
Neuhuber B, and Fischer I
In: K. K. Jain (ed.), Drug delivery to the central nervous system, Series: Neuromethods 45, Humana Press – Springer.
Chapter 10:219-232, 2010. 

“Secretion profile of human bone marrow stromal cells: donorvariability and response to inflammatory stimuli.”
Zhukareva, V., M. Obrocka, J. D. Houle, Fischer I, and B. Neuhuber
Cytokine. 50(3):317-321. PMID:20185331, 2010.   

“Transplantation of human marrow stromal cells and mono-nuclear bone marrow cells into the injured spinal cord.”
Samdani, A. F., C. Paul, R. R. Betz, Fischer I, B. Neuhuber 
Spine. 34(24):2605-2612, 2009.

"Grafting of marrow stromal cells into spinal cord injury: A comparison of minimally-invasive delivery methods"
Paul C, Samdani AF, Betz RR, Fischer I, Neuhuber B
Spine. In press. 2009.

"Effects of plating density and culture time on bone marrow stromal cell characteristics"
Neuhuber B, Swanger SA, Howard L, Mackay A, Fischer I
Exp. Hematol. 36 (9):1176-1185, 2008.

"Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord"
Himes BT, Neuhuber B, Coleman C, Kushner R, Swanger S, Kopen GC, Wagner J, Shumsky JS, Fischer I
Neurorehabilitation and Neural Repair 20(2):278-296, 2006.

"Combining exercise with transplantation of rat bone marrow stromal cells does not improve repair or recovery in rats with thoracic contusion injuries"
Yoshihara H, Shumsky JS, Neuhuber B, Otsuka T, Fischer I, Murray M
Brain Research 1119(1):65-75, 2006.

"Lumbar puncture delivery method of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation"
Bakshi A, Barshinger AL, Swanger SA, Madhvani V, Neuhuber, B, Fischer I
J. Neurotrauma 23(1):55-65, 2006.

Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variation"
Neuhuber B, Himes BT, Shumsky JS, Gallo G, Fischer I
Brain Res. 1035:73-85, 2005.

"Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord"
Swanger SA, Neuhuber B, Himes BT, Bakshi A, Fischer I
Cell Transplant 14(10):775-86, 2005.

"Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: Disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype"
Neuhuber B, Gallo G, Howard L, Kostura L, Mackay A, Fischer I
J. Neurosci. Res. 77:192-204, 2004.

"Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique"
Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I
J. Neurosurgery Spine 3:330-337, 2004.

In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP"
Deng W, Obrocka M, Fischer I, Prockop D
Biol. Biophy. Res Comm. 282:148-152, 2001.

Gene Therapy, Modified Fibroblasts and Matrices 

"Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo."
Jin Y, Ketschek A, Jiang Z, Smith G, Fischer I
J Neurosci Methods. 15;199(2):208-13. PMID: 21600922, 2011.

"Handbook of Clinical Neurolog."
Blesch A, Fischer I, Tuszynski MH
Chapter 37: Gene Therapy, Neurotrophic Factors and Spinal Cord Regeneration, 2009.

"In vitro analysis of a novel injectable polymeric scaffold for spinal cord repair"
Comolli, NK, Neuhuber B, Fischer I, Lowman AM.
Acta Biomat. In press. 2009.

"Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats"
Boyce, VS, Tumolo M, Fischer I, Murray M, Lemay MA.
J. Neurophysiol. 98(4):1988-96, 2007.

"Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder function following spinal contusion injury in rats"
Mitsui T, Fischer I, Shumsky JS, Murray,
Exp. Neurol. 194(2):410-31, 2005.

"Combined effects of neurotrophin secreting transplants, exercise, and serotonergic drug challenge improve function in spinal rats"
Nothias JM, Mitsui T, Shumsky JS, Fischer I, Antonacci MD, Murray M.
Neurorehabil Neural Repair 19(4):296-312, 2005.

"Alginate encapsulated BDNF-producing fibroblast grafts permit recovery of function after spinal cord injury in the absence of immune suppression"
Tobias CA, Han SS, Shumsky JS, Kim D, Tumolo M, Dhoot NO, Wheatley MA, Fischer I, Tessler A, Murray M
J. Neurotrauma 22:138-156, 2005.

"Immunosuppression with either cyclosporine a or FK506 supports survival of transplanted fibroblasts and promotes growth of host axons into the transplant after spinal cord injury"
Hayashi Y, Shumsky JS, Connors T, Otsuka T, Fischer I, Tessler A, Murray M
J Neurotrauma 22(11):1267-81, 2005.

"Combined effects of neurotrophin secreting transplants, exercise and serotonergic drug challenge improve function in spinal rats"
Nothias JM, Mitsui T, Shumsky JS, Fischer I, Anonacci MD, Murray M
Neurorehab Neural Repair 19(4):296-312, 2005.

"Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury"
Bakshi A, Fisher O, Dagci T, Himes BT, Fischer I, Lowman A
J Neurosurgery Spine 3:322-329, 2004.

"Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth"
Dhoot NO, Tobias CA, Fischer I, Wheatley MA
J. Biomedical Materials Research Part A 71:191-200, 2004.

"Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy and provides limited regeneration."
Tobias CA, Shumsky JS, Shibata M, Tuszynski MH, Fischer I, Tessler A, Murray M
Exp. Neurol. 184:97-113, 2003.

"Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury"
Jin Y, Fischer I, Tessler A, Houle JD
Exp Neurol. 177(1):265-75, 2002.

"Grafts of BDNF-producing fibroblasts rescue axotomized rubrospinal neurons and prevent their atrophy"
Liu Y, Himes BT, Murray M, Tessler A, Fischer I
Experimental Neurol. 178:150-164, 2002.

"Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats."
Himes BT, Liu Y, Solowska JM, Snyder EY, Fischer I, Tessler A
J. Neurosci. Res. 65:549-564, 2001.

"Transplantation of genetically modified fibroblasts expressing BDNF in adult rats with a subtotal hemisection improves specific motor and sensory functions."
Kim D, Schallert T, Liu Yi. Browarak,T, Nayeri N, Tessler A, Fischer I, Murray, M
Neurorehabilitation and Neural Repair. 15:141-150, 2001.

"Grafting of encapsulated BDNF-producing fibroblasts into inured spinal cord without immune suppression in adult rats."
Tobias CA, Dhoot NO, Wheatley MA, Tessler A, Murray M, Fischer I
J. Neurotrauma 18:287-301, 2001.

Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons"
Jin Y, Tessler A, Fischer I, Houle JD
Neurorehabilitation and Neural Repair 14:311-317, 2000.

"Improved recombinant retroviral titers utilizing trichostatin A"
Tobias CA, Kim D, Fischer I
BioTechniques, 29:884-89, 2000.

Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons"
Liu Y, Kim Y, Himes T, Chow S, Murray M, Tessler A, Fischer I
J. Neuroscience 19:4370-4387, 1999.

Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses"
Liu Y, Himes T, Tryon B, Moul J, Chow SY, Jin H, Murray M, Tessler A, Fischer I
NeuroReport 9:1075-1079, 1998.

"Application of recombinant adenovirus for in vivo gene delivery to spinal cord."
Liu Y, Himes T, Moul J, Huang W, Chow S, Tessler A, Fischer I
Brain Res. 768:19-29, 1997.

Neuronal Cytoskeleton

"Neurogenesis in Talpha-1 tubulin transgenic mice during development and after injury"
Coksaygan T, Magnus T, Cai J, Mughal M, Lepore A, Xue H, Fischer I, Rao MS
Exp Neurol. 197(2):475-85, 2006.

"Axonal transport of microtubule associated protein 1B (MAP1B) in sciatic nerve of adult rat: distinct transport rates for different isoforms"
Ma D, Himes T, Shea TB, and Fischer I
J. Neurosci. 20:2112-2120, 2000.

"Induction of MAP1B phosphorylation in target-deprived afferent fibers after kainic acid lesion."
Soares S, Fischer I, Ravaille-Veron M, Vincent JD, Nothias F.
J. Comp. Neurol. 396: 193-210, 1998.

"The neurofilament antibody RT97 recognizes a developmentally regulated phosphorylated epitope on microtubule-associated protein 1B"
Johnstone M, Goold RG, Fischer I, Gordon-Weeks PR.
J. Anatomy 199:229-244, 1997.

"Localisation of Microtubule-Associated Protein 1B Phosphorylation Sites Recognised by Monoclonal Antibody SMI-31"
Johnstone M, Goold RG, Bei D, Fischer I, Gordon-Weeks PR
J. Neurochemistry 69:1417-1424, 1997.

"Structural analysis of the proximal region of the microtubule-associated protein 1B promoter"
Liu D, Fischer I
J Neurochem. 69(3):910-9, 1997.

"Tau-like proteins in the nervous system of goldfish"
Liu Y, Xia J, Ma D, Faber DS, Fischer I
Neurochem Res. 22(12):1511-6, 1997.

"Differential regulation of microtubule-associated protein 1B (MAP1B) in rat CNS and PNS during development"
Ma D, Nothias F, Boyne LJ, Fischer I
J. Neurosci. Res. 49:319-332, 1997.

"Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system"
Shea TB, Dahl DC, Nixon RA, Fischer I
J. Neurosci Res. 48(6):515-23, 1997.

"Two alternative promoters direct neuron-specific expression of the rat microtubule-associated protein 1B gene"
Liu D and Fischer I
J. Neurosci. 16:5026-5036, 1996.

"Microtubule-associated protein MAP1B is concentrated in the distal region of growing axons."
Black MM, Slaughter T, Fischer I
J. Neuroscience. 14:857-870, 1994.

Review Articles

“Cellular replacement in spinal cord injury.”
Bonner J, Lepore AC, Rao M, Fischer I
In: Textbook on Neural Repair and Rehabilitation.
Selzer ME, Clarke S, Cohen LG, Duncan PW, Gage FH (eds). In press.
Neural Repair and Plasticity, 2011.

“Intrathecal delivery of stem cells to the spinal cord.”
Neuhuber B, and I. Fischer.  In: K. K. Jain (ed.),
Drug delivery to the central nervous system, Series: Neuromethods 45, Humana Press – Springer. Chapter 10:219-232, 2010.

“Handbook of Clinical Neurology”
Blesch A, Fischer I, Tuszynski MH
Chapter 37: Gene Therapy, Neurotrophic Factors and Spinal Cord Regeneration, 2009

“Cellular replacement in spinal cord injury.”
Fischer I, Lepore AC, Han SSW, Tessler AR.
In: Textbook on Neural Repair and Rehabilitation. Neural Repair and Plasticity.
Selzer ME, Clarke S, Cohen LG, Duncan PW, Gage FH (eds). Pp. 445-467, 2006.

“Cellular  replacement in spinal cord injury.” Fischer I, Tessler AR, Han SSW, Lepore AC. In: Selzer M, ed. Textbook of Neural Repair and Rehabilitation. London: Cambridge University Press, 2006.

"Recommended guidelines for studies of human subjects with spinal cord injury."
D K Anderson, M Beattie, A Blesch, J Bresnahan, M Bunge, D Dietrich, V Dietz B Dobkin, J Fawcett, M Fehlings, I Fischer, R Grossman, J Guest, T Hagg, E D Hall, J Houle, N Kleitman, J McDonald, M Murray, A Privat, P Reier, J Steeves, O Steward, W Tetzlaff, M H Tuszynski, S G Waxman, S Whittemore, J Wolpaw, W Young and B Zheng.
Spinal Cord 43: 453-458, 2005.

"Cellular replacement in spinal cord injury"
Fischer I, Tessler AR, Han SSW, Lepore AC.
Textbook of Neural Repair and Rehabilitation. London: Cambridge University Press, 2006.

"Towards a definition of recovery of function"
Murray M, Fischer I, Smeraski C, Tessler A, Giszter S.
J. Neurotrauma 21:405-413, 2004.

"Plasticity following injury to the adult central nervous system: Is recapitulation of a developmental state worth promoting?"
Emery DL, Royo NC, Fischer I, Saatman KE, McIntosh TK.
J. Neurotrauma 20:1271-1292, 2003.

"Transplantation of genetically modified cells contributes to repair and recovery from spinal injury."
Murray M, Kim D, Liu Y, Tobias C, Tessler A, Fischer I
Brain Res. Reviews 40:292-300, 2002.

"Transplantation and gene therapy: Combined approaches for repair of spinal cord injury."
Murray M, Fischer I
Neuroscientist 7:28-41, 2001.

"Gene Therapy Strategies"
Fischer I and Liu Y
Axonal Regeneration in the Central Nervous System. New York, NY: Marcel Dekker, Inc.; 563-602. 2002.

"Candidate cells for transplantation into the injured CNS"
Fischer I.
Seil FJ, ed. Progress in Brain Research, Vol. 128 Neural Plasticity and Regeneration. Cambridge, MA: Elsevier; 128:253-257. 2000.

"MAP1B expression and microtubule stability in growing and regenerating axons"
Gordon-Weeks PR and Fischer I.
Microscopy Res. and Technique 48:63-74, 2000.

"Neural stem cells and gene therapy: Prospects for repairing the injured spinal cord."
Han S, Fischer I
JAMA 283:2300-2301, 2000.

"Grafting of genetically modified fibroblasts into the injured spinal cord."
Liu Y, Murray M, Tessler A, Fischer I
Seil FJ, ed. Progress in Brain Research, Vol. 128 Neural Plasticity and Regeneration. Cambridge, MA: Elsevier; 128:309-322. 2000.

"Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration."
Nunez J, Fischer I
J. Mol. Neurosci. 8:207-222, 1997.

"Embryonic spinal cord transplants enhance locomotor performance in spinalized newborn rats"
Tessler A, Fischer I, Giszter S, Himes BT, Miya D, Mori F, Murray M.
Adv. Neurol. 72:291-303, 1997.

Teaching

Dr. Fischer is professor and chair of the Department of Neurobiology & Anatomy. He has been with Drexel and its predecessor institutions since 1991. Prior to that he was an assistant professor in the Department of Neurology at Harvard Medical School.

Second Languages
  • Hebrew

Research Location

Department of Neurobiology and Anatomy
2900 Queen Lane
Philadelphia, PA 19129
Phone: 215-991-8400
Fax: 215-843-9082

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