A major initiative in the department is the launch of a new master's degree program in Drug Discovery & Development. This program provides an opportunity for students at Drexel University College of Medicine to have an in-depth exposure to the many different facets of drug discovery and development, ranging from the early identification of a molecular target through the multiple steps involved in preclinical assessment and development, and ultimately to approval and post-marketing activities. The objective is to provide opportunities for students in both M.S. and Ph.D. programs who may be interested in a career in the pharmaceutical and/or biotechnology industry to acquire formal exposure to these processes in the context of their graduate training.
In addition to the development of this program, Dr. Barrett's other research interests involve behavioral pharmacology, animal models of neuropsychiatric and neurological disorders, cognitive neuroscience, CNS plasticity and pain.
Recent publications:
"Application of behavioral techniques to central nervous system (CNS) drug discovery and development"
Barrett, J.E. and Witkin, J.M.
In: Behavioral Pharmacology, to be published in Russian by Binom (Moscow) – Nevsky Dialekt (St. Petersburg), Editors: A.Y. Bespalov, E.E.Zvartau, P. M. Beardsley and J.L. Katz. In press.
"Translational neuroscience: Applications in neurology, psychiatry and neurodevelopmental disorders"
Barrett, J.E., Coyle, J.T. and Williams, M. (Eds.).
Cambridge University Press.Cambridge University Press, 2012.
"Characterization of vabicaserin (SCA-136), a selective 5-HT2C receptor agonist"
Dunlop, J., Watts, S., Barrett, J.E., Coupet, J., Harrison, B., Mazandarani, H., Smith, D., Stack, G., Zhang, J., Zhang, G., and Rosenzweig-Lipson, S.
Journal of Pharmacology and Experimental Therapeutics, 2011, 337, 673-680.
"P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide"
Zhang, L., Su, T-P, Choi, K., Marre, W., Li, C-T., Chung, M-Y, Chen, Y-S., Bi, Y-M., Chou, Y-H., Barker, J.L., Barrett, J.E., Li, X.X., Li, Hi., Ursano, R.
Journal of Psychiatric Research, 2011, 45. 435-441.
"P11 expression and PET in bipolar disorders"
Zhang, L., Li, C-T., Su, T-P, Hu, X-Z., Lanius, R.A., Webster, M.J., Chung, M-Y., Chen, Y-S., Bai, Y-M., Barker, J.L., Barrett, J.E., Li, X-X., Li, H., Benedek, D.M., Ursano, R.
Journal of Psychiatric Research, 2011, 45, 1426-1431.
"MicroRNA modulation in complex regional pain syndrome"
Orlova, I., Alexander, G., Qureshi, R., Sacan, A., Graziano, A., Barrett, J.E., Schwartzman, R. and Ajit, S.
Journal of Translational Medicine, 2011, 9, 195.
Commentary: "mGluR2 Positive Allosteric Modulators: Therapeutic Potential for Treating Cocaine Abuse?"
Barrett, J.E.
Neuropsychopharmacology, 2010, 35, 2007-2008.
"Translating the Translators: Review of Animal and Translational Models for CNS Drug Discovery, Volumes 1-3"
Barrett, J.E.
Edited by Robert A. McArthur and Franco Borsini, Academic Press. Book review. Behavioural Pharmacology, 2009, 20, 561-566.
"Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders"
Su, Tung-Ping, Ming-Yi Chung,Ying-Sheue Chen, Ya-Mei Bi, Yuan-Hwa Chou, Jeffery L. Barker, James E. Barrett, Dragan Maric, Xiao Xia Li, He Li, David D. Benedek, Robert Ursano, Lei Zhang.
Journal of Psychiatric Research, 2009, 43, 1078-1085.
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