Dr. Grothusen's background is in biochemistry and bioanalytical methods. In the past he has been involved in animal research in neurodegenerative diseases and pain using techniques such as intracerebral microdialysis. His present area of interest is chronic pain and the use of non-invasive methods for sensory and autonomic nervous system testing in humans. He runs the clinical quantitative sensory and autonomic nervous system testing laboratory for the department.
Education
1976: B.S., Biology, Pennsylvania State University
1983: Ph.D., Biochemistry, Clemson University
Publications
Schwartzman RJ, Grothusen JR: Brachial plexus traction injury: a controlled, quantitative study. submitted to Neurology.
"Complex regional pain syndromes"
Singh MK, Patel J, Grothusen J, Foye, PM
Review for emedicine.com.
"Neuropathic central pain: epidemiology, etiology, and treatment options"
Schwartzman RJ, Grothusen J, Kiefer TR, Rohr P
Archives of Neurology, Oct;58(10):1547-50, 2001.
"Quantitative sensory studies in complex regional pain syndrome type 1/RSD"
Tahmoush AJ, Schwartzman RJ, Hopp JL, Grothusen JR
Clinical Journal of Pain, 16(4):340-4, 2000.
"Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats"
Alexander GM, Grothusen JR, Gordon SW and Schwartzman RJ
Brain Research, 766: 1-10, 1997.
"Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood transport of levodopa in naive and MPTP parkinsonian monkeys"
Alexander GM, Schwartzman RJ, Grothusen JR, Gordon SW
Neurology, 44:1491-1499, 1994.
"beta2-Adrenergic agonist as adjunct therapy to levodopa in Parkinson's disease"
Alexander GM, Schwartzman RJ, Nukes TA, Grothusen JR and Hooker, MA
Neurology, 44:1511-1513, 1994.
"Changes in brain dopamine receptors in MPTP parkinsonian monkeys following l-dopa treatment"
Alexander GM, Schwartzman RJ, Grothusen JR, Brainard DL and Gordon SW
Brain Research, 625:276-282, 1993.
"N-methyl-4- phenylpyridinium (MPP+) potentiates the killing of cultured hepatocytes by catecholamines"
Snyder JW, Alexander GM, Ferraro TN, Grothusen JR and Farber JL
Chem.-Biol. Interactions, 88:209-223, 1993.
"Changes in brain catecholamines and dopamine uptake sites at different stages of MPTP parkinsonism in monkeys"
Alexander GM, Schwartzman RJ, Brainard DL, Gordon SW and Grothusen JR
Brain Res., 588:261-269, 1992.
"Dopamine receptor changes in untreated and (+)-PHNO-treated MPTP parkinsonian primates"
Alexander GM, Brainard DL, Gordon SW, Hichens M, Grothusen JR and Schwartzman RJ
Brain Research, 547:181-189, 1991.
"Comparison of the effects of intracerebrally administered MPP+ (1-methyl-4-phenylpyridinium) in three species: microdialysis of dopamine and metabolites in mouse, rat and monkey striatum"
Rollema, H, Alexander, GM, Grothusen JR, Matos, FF and Castagnoli, N
Neurosci. Lett., 106:275-281, 1989.
"Gyroxin, a neurotoxin from the venom of crotalus durissus terrificus, is a thrombin-like enzyme"
Alexander GM, Grothusen JR, Zepeda H and Schwartzman RJ
Toxicon, 26:953-960, 1988.
"Intracerebral uric acid production in brain infection with MHV-4 virus"
Knobler RL, Alexander GM, Grothusen JR and Lublin FD
Neurology 38:121, 1988.
"Flow dependent changes in the effective surface area of microdialysis probes"
Alexander GM, Grothusen JR and Schwartzman RJ
Life Sci., 43:595-601, 1988.
"Metabolic study of gyroxin, a central vestibular stimulant"
Schwartzman RJ, Alexander GM, Grothusen JR, and Wilpizeski C
Neurology 38:369, 1988.
"Cerebral metabolism of parkinsonian primates 21 days after MPTP exposure"
Schwartzman RJ, Alexander GM, Ferraro TN, Grothusen JR and Stahl SM
Neurol.,102:307-313, 1988.
"Intracerebral dialysis in MPTP parkinsonian primates"
Alexander GM, Grothusen JR and Schwartzman RJ
Ann. Neurol., 22:144-145, 1987.
"Stereoselectivity of acetylcholinesterase, Arylester hydrolase and chymotrypsin toward 4-nitrophenyl alkyl (phenyl) phosphinates"
Grothusen JR and Brown TM
Pestic. Biochem. Physiol., 26:100-106, 1986.
"Hydrolysis of 4-nitrophenyl organophosphinates by arylester hydrolase from rabbit serum"
Grothusen JR, Bryson PK, Zimmerman JK and Brown TM
J. Ag. Food Chem., 34(3):513- 515, 1986.
"High performance liquid chromatography of 4-nitrophenyl organophosphinates and chiral-phase separation of enantiomers"
Brown TM and Grothusen JR
J. Chromatogr., 294:390-396, 1984.
"A simple calculator program for flexible sequential sampling of insects"
Shepard M and Grothusen JR
Bull. Ent. Soc. Amer., 30:35-37, 1984.
"A simple method of analyzing profiles in time-difference direct optical scanning gel chromatography"
Grothusen JR and Zimmerman JK
Biophys. Chem. 20:299-304, 1984.
"Characterization of a homogeneous arginyl-and lysyl-tRNA synthetase complex isolated from rat liver"
Hilderman RJ, Zimmerman JK, Dange CV and Grothusen JR
J. Biol. Chem. 258(22):13592-13596, 1983.
"A re-examination of some properties of fatty acyl-CoA micelles"
Powell GL, Grothusen JR, Zimmerman JK, Evans CA and Fish WW
J.Biol.Chem., 256(24):12740-12747, 1981.
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