Dr. Grothusen's background is in biochemistry and bioanalytical methods. In the past he has been involved in animal research in neurodegenerative diseases and pain using techniques such as intracerebral microdialysis. His present area of interest is chronic pain and the use of non-invasive methods for sensory and autonomic nervous system testing in humans. He runs the clinical quantitative sensory and autonomic nervous system testing laboratory for the department.
Education
1976: B.S., Biology, Pennsylvania State University
1983: Ph.D., Biochemistry, Clemson University
Publications
"Changes in plasma cytokines and their soluble receptors in complex regional pain syndrome"
Alexander GM, Peterlin BL, Perreault MJ, Grothusen JR, Schwartzman RJ
J Pain Jan;13(1):10-20, 2012*
"Laser Doppler imaging: Usefulness in Chronic Pain Medicine"
Grothusen JR, Schwartzman RJ
Pain Physician 14:491-498, 2011
"The use of ketamine in complex regional pain syndrome: possible mechanisms"
Schwartzman RJ, Alexander GM, Grothusen J
Expert Rev Neurother, 11:719-734, 2011
"Syncope in complex regional pain syndrome"
Smith JA, Karalis DG, Rosso AL, Grothusen JR, Hessen SE, Schwartzman RJ
Clinical Cardiology 34(4):222-225, 2011
"Elevated blood levels of inflammatory monocytes (CD14+ CD16+) in patients with complex regional pain syndrome"
Ritz BW, Alexander GM, Nogusa S, Perreault MJ, Peterlin BL, Grothusen JR, Schwartzman RJ
Clinical and Experimental Immunology 164(1):108-117, 2011
"Efficacy of Five Day Continuous Lidocaine Infusion for the Treatment of Refractory Complex Regional Pain Syndrome"
Schwartzman RJ, Patel M, Grothusen JR, Alexander GM
Pain Medicine, 10(2):401-412, 2009*
"Atypical Chest Pain: Evidence of Intercostobrachial Nerve Sensitization in Complex Regional Pain Syndrome"
Rasmussen JW, Grothusen JR, Rosso A, Schwartzman RJ
Pain Physician, 12:E329-E334, 2009*
"Pain Score Meter" letter to editor
Grothusen JR
Continuous Pain Practice 9(5): 404, 2009
"Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: A double-blind placebo controlled study"
Schwartzman RJ, Alexander GM, Grothusen JR, Paylor T, Reichenberger E, Perreault M
Pain 147:107-115, 2009*
"A Pilot Open-Label Study of the Efficacy of Subanesthetic Isomeric S(+)-Ketamine in Refractory CRPS Patients"
Kiefer, RT, Rohr, P, Ploppa, A, Nohe, B, Dieterich, HJ, Grothusen, J, Altemeyer, KH, Unertl, K, Schwartzman.
Pain Medicine, 9(1):44-54, 2008*
"Efficacy of ketamine in anesthetic dosage for the treatment of refractory Complex Regional Pain Syndrome: An open-label phase II study"
Kiefer RT, Rohr P, Ploppa A, Dieterich HJ, Grothusen J, Koffler S, Altemeyer KH, Unertl K, Schwartzman RJ
Pain Medicine, 9(8):1173-201, 2008*
"Brachial plexus traction injury: Quantification of Sensory Abnormalities"
Schwartzman RJ, Grothusen JR
Pain Medicine, 9(7):950-957, 2008*
"Pathophysiology of complex regional pain syndrome"
Schwartzman RJ, Alexander GM, Grothusen J
Expert Rev. Neurotherapeutics, 6(5):669-681, 2006
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