Image of Salvino, Joseph

Joseph M. Salvino, PhD

Professor

  • Department:Pharmacology & Physiology
  • Education: Postdoctoral Fellowship, University of Pennsylvania; PhD in Organic Chemistry - Brown University; MS in Chemistry - Bucknell University
Research Overview

Research Interests: Medicinal chemistry, Hit-to-Lead/Lead optimization, Oncology, Antibacterial/Antiviral, Pain, and Inflammation. Biologically relevant targets including G-protein coupled receptors, enzyme inhibitors, and transporters. High-throughput chemistry/Parallel synthesis, Solution and Solid Phase Chemistry.

In the News

Research

My research focuses on the design and synthesis of novel chemical matter to probe biologically relevant targets. As a medicinal chemist I can collaborate across therapeutic areas and provide small molecule probes as tools to understand the pharmacological relevance of a therapeutic target. My focus is on providing small molecule analogs to probe the structure activity relationships within a chemical series in order to optimize a class of molecules to provide a potential new therapeutic agent. Optimization of a lead compound involves improving binding affinity and functional efficacy in biochemical and cellular assays, as well as improving drug-like molecular properties such as water solubility, chemical and metabolic stability, and in vivo exposure and pharmacokinetic properties. I have extensive experience in rational drug design utilizing X-ray crystal structures of protein-ligand complexes in drug design, as well as predictive homology models of ligand-receptor complexes.

My current collaborations are focused on the design of novel small molecule chemokine antagonists which target circulating tumor cells or provide a means to modulate the activation of microglia in the central nervous system, novel small molecule modulators of the ER stress response, and lead optimization of a new chemical series providing a novel therapeutic approach to the treatment of HIV-1 infection.

Selected References

"Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test"
Tripathy R, McHugh RJ, Bacon ER, Salvino JM, Morton GC, Aimone LD, Huang Z, Mathiasen JR, DiCamillo A, Huffman MJ, et al
Bioorganic & Medicinal Chemistry Letters, 22(3),1421-1426 (2012)

"Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists"
Sundar BG, Bailey TR, Dunn DD, Bacon ER, Salvino JM, Morton GC, Aimone LD, Zeqi H, Mathiasen JR, Dicamillo A, et al
Bioorganic & Medicinal Chemistry Letters, 22(1),120-123 (2012)

"Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor"
Hoveyda HR, Roy M, Blanc S, Noel S, Salvino JM, Ator MA, and Fraser G
Bioorganic & Medicinal Chemistry Letters, 21(7), 1991-1996 (2011)

"Glycine Transporter (GlyT1) Inhibitors with Reduced Residence Time Increase Prepulse Inhibition without Inducing Hyperlocomotion in DBA/2 Mice"
Kopec K, Flood DG, Gasior M, McKenna BA, Zuvich E, Schreiber J, Salvino JM, Durkin JT, Ator MA, and Marino MJ
Biochemical Pharmacology, 80(9),1407-1417 (2010)

"Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics"
Zhou J, Bhattacharjee A, Chen S, Chen Y, Duffy E, Farmer J, Goldberg J, Hanselmann R, Ippolito JA, Lou R, Orbin A, Oyelere A, Salvino J, Springer D, Tran J, Wang D, Wu Y, and Johnson G
Bioorganic & Medicinal Chemistry Letters, 18(23),6175-6178 (2008)

"Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics"
Zhou J, Bhattacharjee A, Chen S, Chen Y, Duffy E, Farmer J, Goldberg J, Hanselmann R, Ippolito JA, Lou R, Orbin A, Oyelere A, Salvino J, Springer D, Tran J, Wang D, Wu Y, and Johnson G
Bioorganic & Medicinal Chemistry Letters, 18(23),6179-6183 (2008)

"Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery"
Ghose AK, Herbertz T, Pippin DA, Salvino JM, and Mallamo JP
Journal of Medicinal Chemistry, 51(17),5149-5171 (2008)

"Preparation of tetrahydrobenzofuropyridine derivatives for use in treatment of diseases mediated by one or more members of serotonin receptors family"
Bacon ER, Bailey TR, Dunn DD, Hostetler GA, Mchugh RJ, Morton GC, Rosse GC, Salvino JM, Sundar BG, and Tripathy R
PCT Int. Appl., WO 2011087712 A2 20110721 (2011)

"A preparation of oxazole-containing sulfonamide derivatives"
Goldberg JA, Chen S, Farmer JJ, Orbin A, Salvino JM, and Zhou J (Rib-X Pharmaceutical, Inc., USA)
PCT Int. Appl., 65 pp. CODEN: PIXXD2 WO 2005070904 A2 20050804 (2005)

"Preparation of halogenated biaryl oxazolidinones as antiinflammatory agents"
Chen S, Zhou J, Wu Y, Wang D, Salvino JM, Oyelere AK, and Lou R (Rib-X Pharmaceuticals, Inc., USA; Bhattacharjee A, Chen Y)
PCT Int. Appl., 123 pp. CODEN: PIXXD2 WO 2005061468 A1 20050707 (2005)

"Preparation of bifunctional macrolide heterocyclic azithromycin analogs as potential anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents"
Farmer JJ, Goldberg JA, Oyelere AK, Salvino JM, Springer DM, and Tran J (Rib-X Pharmaceuticals, Inc., USA)
PCT Int. Appl., 81 pp. CODEN: PIXXD2 WO 2005049632 A1 20050602 (2005)

"Preparation of biaryl heterocyclic compounds and methods of making and using the same in pharmaceutical applications"
Zhou J, Bhattacharjee A, Chen S, Chen Y, Farmer JJ, Goldberg JA, Hanselmann R, Lou R, Orbin A, Oyelere AK, Salvino JM, Springer DM, Tran J, Wang D, and Wu Y (Rib-X Pharmaceuticals, Inc., USA)
PCT Int. Appl., 259 pp. CODEN: PIXXD2 WO 2005019211 A2 20050303 (2005)

"Preparation of N-arylheteroaryls, in particular N-phenylpiperazinyl methanones, as inhibitors of tubulin polymerization and their compositions for treatment of cancer"
Le-Brun A, Thompson F, Tiraboschi G, Mailliet P, and Salvino JM (Aventis Pharma S.A., Fr.)
PCT Int. Appl., 197 pp. CODEN: PIXXD2 WO 2004078732 A1 20040916 (2004)

"N-arylheteroaromatic products, compositions containing them, and use"
Le Brun A, Thompson F, Tiraboschi G, Salvino J, and Mailliet P (Aventis Pharma SA, Fr.)
Fr. Demande, 80 pp. CODEN: FRXXBL FR 2850379 A1 20040730, Patent written in French, Application: FR 2003-894 20030128. AN 2004:611924 (2004)

Teaching

Joseph Salvino, PhD, is a professor in the Department of Pharmacology and Physiology.

Academic Location

Department of Pharmacology & Physiology
245 North 15th Street
Mail Stop #488
Philadelphia, PA 19102
Phone: 610-256-6571
Fax: 215-762-2299

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