Selected Research Publications
"Interleukin-6 and Oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73"
Liang H, Block TM, Wang M, Nefsky B, Long R, Hafner J, Mehta AS, Marrero J, Gish R, and PA Norton
Cancer Biomarkers, in press, 2012.
"Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue"
Mehta A, Norton P, Liang H, Comunale MA, Wang M, Rodemich-Betesh L, Koszycki A, Noda K, Miyoshi E, and T Block
Cancer Epidemiol. Biomarkers Prev., 21: 925-933, 2012.
"Linkage specific fucosylation of alpha-1-antitrypsin in patients liver cirrhosis and cancer patients: Implications for a biomarker of hepatocellular carcinoma"
Comunale MA, Rodemich-Betesh L, Hafner J, Wang M, Norton P, Di Bisceglie AM, Block T and A Mehta
PLoS One 5, e12419, 2010.
"Glucosidase inhibition results in enhanced presentation by MHC class I of de-N-glycosylated hepatitis B envelope protein epitopes in vitro and in vivo"
Norton PA, Menne S, Sinnathamby G, Betesh L, Cote PJ, Philip R, Mehta AS, Tennant BC and TM Block
Hepatology, 52: 1242-1250, 2010.
"Inhibition of cellular glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I"
Simsek E, Sinnathamby G, Block TM, Liu Y, Philip R, Mehta AS, and PA Norton.
Virology, 384:12-15, 2009.
"The role of the downstream signal sequences in the maturation of the HBV Middle Surface glycoprotein: development of a novel therapeutic vaccine candidate"
Liu Y, Simsek E, Norton P, Sinnathamby G, Philip R, Block TM, Zhou T, and AS Mehta.
Virology, 365: 10-19, 2007.
"N-linked glycosylation of the liver cancer biomarker GP73"
Norton PA, Comunale MA, Krakover J, Rodemich L, Pirog N, D'Amelio A, Philip R, Mehta AS, and TM Block.
J. Cell. Biochem., 104:136-149, 2007.
"A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion"
Dougherty AM., Guo H, Westby G, Liu Y, Simsek E, Guo J-T, Mehta A, Norton P, Gu B, Block TM, and A Cuconati.
Antimicrob. Agents Chemother., 51:4427-4437, 2007.
"Imino sugars as antiviral agents"
Norton PA, Gu B, and TM Block.
In Iminosugars: From Synthesis to Therapeutic Applications. P. Compain and O.R. Martin, eds., John Wiley & Sons, Ltd., London, 209-224, 2007.
"Assays for glucosidase inhibitors with potential antiviral activities: secreted alkaline phosphatase as a surrogate marker"
Norton PA, Conyers B, Gong Q, Steel LF, Block TM, and AS Mehta.
J. Virol. Methods, 124: 167-172, 2005.
"Activation of fibronectin gene expression by Hepatitis B virus X antigen"
Norton PA, Reis HMGPV, Prince S, Larkin J, Pan J, Liu J, Gong Q, Zhu M, and MA Feitelson.
J. Viral. Hep., 11: 332-341, 2004.
"Hepatitis B virus-mediated changes in apolipoprotein mRNA abundance in cultured hepatoma cells"
Norton PA, Gong Q, Mehta AS, Lu X, and TM Block.
J. Virol., 77: 5503-5506, 2003.
"Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and beta 1-adrenergic signal transduction"
Wu J, Liu S-L, Zhu JL, Norton PA, Nojiri S, Hoek JB, and MA Zern.
J. Biol. Chem., 275: 22213-22219, 2000.
"Rapamycin inhibits stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis"
Zhu J, Wu J, Frizell E, Liu S-L, Bashey R, Rubin R, Norton P, and MA Zern.
Gastroenterol., 117: 1198-1204, 1999.
"A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by nuclear factor-kappaB (NF-kappaB)"
Mirza A, Liu S-L, Frizell E, Zhu J, Maddukuri S, Martinez J, Davies P, Schwarting R, Norton P, and MA Zern.
Am. J. Physiol., 35: G281-G288, 1997.