Biography
Dr. Markin received a M.S. in Radiophysics from Rostov State University, Russia in 1992. Since this year, he joined the Laboratory for Neuroinformatics of Sensory and Motor Systems at A. B. Kogan Research Institute for Neurocybernetics, Rostov State University as a junior researcher. In 1997, he received his Ph.D. in Computer Science from Rostov State University. In 1998 – 1999, he was a Visiting Scientist in the Center for Artificial Vision Research, Seoul National University, Seoul, Korea. In 2000-2002, he held Research Scholar position in the laboratory of Dr. Simon Giszter at the Department of Neurobiology and Anatomy, Drexel University College of Medicine. Later, in 2002-2004 he held a Research Associate position in the laboratory of Dr. Ilya Rybak at Drexel University School of Biomedical Engineering. He was also a Visiting Scientist in the Spinal Cord Research Center, University of Manitoba, Winnipeg, Canada. In 2006, Markin joined the Department of Neurobiology and Anatomy at Drexel University College of Medicine as a Research Assistant Professor.
Research Interests
Markin’s research interests include: computational modeling of biological neurons and neural networks; kinetics of ionic channels and their role in the neuronal pattern formation cross-level integration of sub-cellular, cellular, network and systems brain/neural mechanisms; spatio-temporal dynamics of activity and oscillations in biological neural networks; designing computational tools for the modeling of biological neural networks; designing computational tools for the processing and analysis of experimental data.
Motor Control (general issues):
• Neural control of voluntary and automatic movements
• Neurogenesis of the locomotor rhythm and neural control of locomotion
• Neurogenesis of the respiratory rhythm and neural control of breathing
Neurogenesis of the locomotor rhythm and neural control of locomotion:
• Cellular and network mechanisms for locomotor rhythm generation in mammalian spinal cord
• Afferent and supra-spinal control of the spinal central pattern generator (CPG) during walking
• Applications to restoration of the locomotor function after spinal cord injuries and diseases
Neurogenesis of the respiratory rhythm and neural control of breathing:
• Network mechanisms for rhythm generation and pattern formation in the respiratory brainstem
• Spatial organization of the brainstem respiratory center
• The role of and interaction between cellular (e.g., ionic channels, pacemaker properties) and network mechanisms in the respiratory rhythm and pattern generation
Markin is an investigator in two major project supported by the NINDS/NIH: the Bioengineering Research Partnership (BRP) project “Spinal control of locomotion: studies and applications” and Collaborative Research in Computational NeuroScience (CRCNS) project “State-dependent neural mechanisms for respiratory pattern generation”.
Selected Publications
"Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation"
Rybak IA, Abdala, APL, Markin SN, Paton JFR, and Smith JC
Progress in Brain Research, 165: 201-220, 2007.
Method to Detect Impulses of Various Duration Generated by Purkinje Cells of Cerebellar Cortex
Markin SN, Podladchikova LN, and Dunin-Barkowski WL
Pattern Recognition and Image Analysis, V. 15, No. 6, 672-675, 2005.
"Generation of respiratory rhythm in a ponto-medullary neural network model".
Shevtsova NA, Markin SN, and Rybak IA
Neurocomputers: development and application 11, 26-40, 2004.
"Modeling the spinal cord neural circuitry controlling cat hindlimb movement during locomotion"
Ivashko DG, Prilutsky BI, Markin SN, Chapin JK, and Rybak IA
Neurocomputing 52-54: 621-629, 2002.
"Activity properties of branches of a climbing fiber which control different Purkinje cells"
Dunin-Barkowski, WL, Markin SN, and Podladchikova LN
Biophysika, 44, 4, 1999.
"Estimation of Purkinje cells complex and simple spikes contribution to local field potentials of the cerebellar cortex"
Dunin-Barkowski WL, Markin SN, and Podladchikova LN
Biophysika, 42,2: 516-521, 1997. |