ACADEMIC CAREER
Since 1987, Dr. Joshi has taught undergraduate, postgraduate and doctoral students and trained doctoral and post-doctoral fellows in research. He has been mentoring graduates and medical students, who now have successful careers in medicine, academia and the pharmaceutical industry.
Research Fellows with Dr. Joshi: Utku Ercan, Bhaswati Sen, Nachiket Vaze, Adam Yost, Rose Mustafa, Krista Lewandowski, Lindsay Pomykala, Sania Mahmood.
Subjects Taught: Medical Microbiology, Pathology, Parasitology, Communicable Diseases, Hospital-Acquired Infections and Infection Control Methods.
Visiting Dept Faculty Fellow: University of Rochester Medical Center, Rochester, New York
Sr. Research Fellowship & Adjunct Faculty: Thomas Jefferson University Medical College, Philadelphia, PA
Certification: Infection Control, State of New York
Board Eligible: For American Board of Medical Microbiology
Postgraduate Training: Medical Microbiology, and Biochemistry & Cell Biology
Medical Training: Medical Microbiology, as well as Family Medicine and Alternative Medicine. Practicing physician since 1986
RESEARCH
Joshi’s research areas are related to bacterial pathogenesis. He has extensive experience in the areas of nosocomial infection, antimicrobial resistance, and molecular and clinical epidemiology. He is also working in the area of host cellular responses to bacterial pathogens and/or their virulence products, notably of Rickettsia, Acinetobacter, MRSA, and botulinum toxins. Joshi has developed several in vitro and in vivo assays, and has expertise in immunocytochemical (ICC) and immunohistochemical (IHC) detection systems and microscopy. Dr. Joshi and Dr. Brooks work together and have developed several research proposals jointly; Surgical Infections Research (SIR) is one the major intiatives. Some of the current topics of research in the lab are:
• Exploring the antimicrobial effect of floating electrode DBD (FE-DBD) atmospheric non-thermal plasma.
• Antimicrobial/antitoxin novel small molecule, and natural product
• Molecular and clinical epidemiology of surgical site infections, ICU
• Host responses and pathogenesis of MRSA, MDR-Acinetobacter, botulinum toxin and Rickettsia.
CLINICAL TRIALS
• Novel beta-lactamase inhibitors with carbapenems against complicated intra-abdomenal infection.
• Clinical response and efficacy of novel beta-lactamase inhibitor in urinary tract infection therapeutic regime.
• Effect of novel antimicrobial solution and it's clinical efficacy in the management of atopic dermatitis (being submitted).
SELECTED PUBLICATIONS (See all Suresh Joshi's publications in PubMed.)
"Clinical demography and characteristics of carbapenem-resistant Acinetobacter baumannii infection in a tertiary care university hospital in Philadelphia"
Vaze N, Emery CL, Brooks AD, Joshi SG
American Journal of Infection Control (being submitted) (2012)
"An analysis of the mechanisms that underlie absorption of botulinum toxin by the inhalation route"
Al-Saleem FH, Ancharski DM, Joshi SG, Elias MD, Singh A, Nasser Z, and Simposn LL
Infection and Immunity (under review) (2012)
"Plasma Acid: Water Treated by Dielectric Barrier Discharge"
Shainsky N, Dobrynin D, Ercan U, Joshi SG, Ji H, Brooks A, Fridman G, Cho Y, Fridman A, Friedman G
Plasma Processes and Polymers 2012, March 2 (DOI: 10.1002/ppap.201100084)
"Porcine intact and wounded skin responses to FE-DBD atmospheric non-thermal plasma"
Wu AS, Kalghatgi S, Dobrynin D, Sensenig R, Podolsky E, Dulaimi E, Paff M, Garcia K, Wasko K, Fridman G, Balasubramanian M, Ownbey R, Barbee KA, Fridman A, Friedman G, Joshi SG, and Brooks AD
Journal of Surgical Research 2012 Mar 10 (In Press)
"Detection of biologically active botulinum neurotoxin-A from serum using high throughput FRET-assay"
Joshi SG
Journal of Pharmacological & Toxicological Methods (2011) [Epub ahead of print; PMID:22178409]
"Occurance of and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) at a teaching hospital in Philadelphia"
Gomes S, Altafi S, Garcia K, Emery C, Hamilton R, Brooks AD, and Joshi SG
American Journal of Infection Control (2011) [Epub ahead of print; PMID: 21864946]
"Isolation of Burkholderia cenocepacia J2315 from non-cystic fibrosis pediatric patients from India"
Satpute MG, Telang NV, Dhakephalkar PK, Niphadkar KB, and Joshi SG
American Journal of Infection Control, 39(4):e21-23 (2011)
"Fulminating septicemia due to persistent pan-resistant community-acquired MBL (IMP1)-positive Acinetobacter baumannii"
Telang NV, Satpute MG, Dhakephalkar PK, Niphadkar KB, and Joshi SG
Indian Journal of Pathology and Microbiology, 54(1): 180-182 (2011)
"Modulation of botulinum toxin-induced changes in neuromuscular function with antibodies directed against recombinant polypeptides or fragments"
Joshi SG, Elias MD, Singh AK, Al-Saleem FH, Ancharski DM, Nasser Z, Takahashi T, and Simpson LL
Neuroscience, 179: 208-222 (2011)
"Non-thermal dielectric-barrier discharge (DBD) plasma-induced inactivation involves oxidative-DNA damage and membrane lipid peroxidation in Escherichia coli"
Joshi SG, Cooper M, Yost A, Paff M, Ercan UK, Fridman G, Friedman G, Fridman A, and Brooks AD
Antimicrobial Agents and Chemotherapy, 52: 1053-1062 (2011)
"Live pig skin tissue and wound toxicity of cold plasma treatment"
Dobrynin D, Wu A, Kalghatgi S, Park S, Shainsky N, Wasko K, Dulaimi E, Ownbey R, Sensenig R, Joshi SG, and Brooks AD
Plasma Medicine, 1(1): 93-108 (2010)
"Biological responses of Bacillus stratosphericus to floating electrode-dielectric barrier discharge plasma treatment"
Cooper M, Fridman G, Fridman A, and Joshi SG
Journal of Applied Microbiology, 109: 2039-2048 (2010)
"Control of methicillin-resistant Staphylococcus aureus (MRSA) in planktonic form and biofilms: a biocidal efficacy study of non-thermal DBD-plasma"
Joshi SG, Paff M, Friedman G, Fridman G, Fridman A, and Brooks AD
American Journal of Infection Control, 38: 293-301 (2010)
"An increased incidence of biofilm-producing MDR methicillin-resistant Staphylococcus aureus in a tertiary care hospital from India: Two years study"
Telang NV, Satpute MG, Niphadkar KB, and Joshi SG
American Journal of Infection Control, 38: 165-166 (2010)
"PER-1 type-extended-spectrum-beta-lactamase-producing Acinetobacter baumannii clinical isolates from India"
Litake GM, Ghole VS, Niphadkar KB, and Joshi SG
International Journal of Antimicrobial Agents, 34: 280-283 (2009)
"Localization of the sites and characterization of the mechanisms by which anti-light chain antibodies neutralize the actions of the botulinum holotoxin"
Takahashi T, Joshi SG, Al-Saleem FH, Ancharski D, Singh AK, Nisser Z, and Simpson LL
Vaccine, 27: 2616-2624 (2009)
"The role of systemic handling in the pathophysiologic actions of botulinum toxin"
Al-Saleem FH, Ancharski DM, Ravichandran E, Joshi SG, Singh AK, Gong Y, and Simpson LL
Journal of Pharmacology & Experimental Therapeutics, 326: 856-863 (2008)
COLLABORATIONS
• A.J. Drexel Plasma Institute, Drexel University, Philadelphia
• Center for Botulism and Biodefense Research (CBBR), Thomas Jefferson University
• Institute of Molecular Medicine and Infectious Diseases, Dexel University, CoM
• School of Biomedical Engineering, Science and Health Systems, Drexel University
• KEM Hospital & Research Center, Pune, and University of Pune, Pune (India)
• Hadassah Hebrew University Medical Center, Jerusalem (Israel)
HONORS
• UNESCO-ASM Visiting Resource Person, 2002, 2004
• National Judge & Evaluator for Annual Biomed Research Conf for Minority Students (ABRCMS), 2008, 2009, 2010
• International Mentoring Program & Minority Mentoring Program, American Society for Microbiology, and Infect Dis Society of America.
• Editorial Board Service to BMC Infect Dis; Surgery: Current Research; World J Clin Infect Dis; Afr J Infect Dis (Academic Journals). |