Biography
Dr. Marchenko received his M.D. in general surgery from Dnipropetrovsk Medical Institute (Ukraine) in 1982 and his Ph.D. in biology and medicine from Bogomoletz Institute of Physiology of Ukraine Academy of Science in 1997. He started his practice as general surgeon and later as neurosurgeon in emergency hospital services in Ukraine. His thesis was devoted to central mechanisms of respiratory rhythm generation.
Marchenko received his scientific experience mostly in the U.S. He was a research fellow at Albert Enstein College of Medicine, Bronx, N.Y. (1997-1998), New Jersey Medical School (1998-2000), University of Pennsylvania (2000-2003), and a Research Associate III in University of Delaware (2003-2008), and Research Assistant A in the Daniel Baugh Institute for Functional Genomics and Computational Biology, Philadelphia (2008-2009).
Research Interests
• neural control of cardiovascular and respiratory function
• synchronous oscillations in motor neuron pools
• optical imaging of electrical activity of respiratory and cardiovascular bulbospinal networks
• spike train encoding and decoding
Research goals of Marchenko are focused mainly on central mechanisms of cardiorespiratory and locomotor network plasticity and reconfiguration during transition from normal breathing to gasping under deep anoxia. By using experimental approaches such as in vivo and in situ electrophysiology, functional optical imaging, microinjection techniques, and application of information theory, he seeks to understand how different type of neuronal cells, neurotransmitters and second-messenger intracellular systems are involved in changing of sensory information processing from peripheral (respiratory and cardiovascular) receptors and synchronous activity of motoneuron pools under such pathological condition as severe hypoxia.
Selected Publications
Cardiovascular and Respiratory Control
Marchenko, V.A., Voitenko, L.P., Volgin, D.V., Fenik, V.B., Vasilenko, D.A. Pacemaker
Properties of Respiratory Neurons of the Ventrolateral Medullary Regions in Early Postnatal
Rats. Nerofiziologia/Neurophysiology, Plenum Press, NY, USA, 28(6): 214-222, 1996.
Marchenko, V., Sapru, H.N. Different patterns of respiratory and cardiovascular responses
elicited by chemical of dorsal medulla in the rat. Brain Research, 857(1-2): 99-109, 2000.
Marchenko, V., Sapru, H.N. Cardiovascular responses to chemical stimulation of the lateral
tegmental field and adjacent medullary reticular formation in the rat. Brain Research, 977: 247-
260, 2003.
Functional Optical Imaging
Fisher JAN, Marchenko VA, Yodh AG, Rogers RF. Spatiotemporal activity patterns during
respiratory rhythmogenesis in the rat ventrolateral medulla. J. Neurophysiol. 95: 1982–1991, 2006.
Synchronous Oscillations among Motor Neurons
Marchenko V, Rogers RF. Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. Am. J. Physiol. 291: R1414–R1429, 2006.
Marchenko V, Rogers RF. Time-frequency coherence analysis of phrenic and hypoglossal activity in the decerebrate rat during eupnea, hyperpnea, and gasping. Am. J. Physiol. 291: R1430–R1442, 2006.
Marchenko V, Rogers RF. Temperature- and state-dependence of dynamic phrenic oscillations in the decerebrate juvenile rat. Am. J. Physiol. 293: R2323–R2335, 2007.
Marchenko V, Rogers RF. GABAAergic and glycinergic inhibition in the phrenic nucleus organizes and couples fast oscillations in motor output. J. Neurophysiol. 101: 2134–2145, 2009.
Information Transfer & Spike Train Encoding
Marchenko V, Rogers RF. Retention of lung distention information in pump cell spike trains. Am. J. Physiol. 293: R343–R353, 2007.
Chen Y, Marchenko V, Rogers RF. Classification performance of a sparse representation of instantaneous firing rate. Neurosci Lett. 439: 47–51, 2008.
Chen Y, Marchenko V, Rogers RF. Joint probability-based neuronal spike train classification. Computational & Mathematical Methods in Medicine in press 2009. |