Image of Su, Ying-Hsiu

Ying-Hsiu Su, PhD

Associate Professor

  • Department:Microbiology and Immunology
  • Education: PhD - University of South Alabama (1992)
Research Overview

Research interests: Explore the potential of transrenal (circulation derived) DNA biomarkers in urine for cancer screening and disease management

Research staff: Surbhi Jain, PhD (Postdoctoral fellow), Selena Lin, MS (PhD student)

Research

We are one of few pioneers to explore the potential to use of DNA in urine for cancer detection. This study is supported by the National Cancer Institute. In our previous studies, we have shown that DNA recovered from urine represents not only cells of the urinary tract, but also those from apoptotic cells of the distal sites in the body. Thus, DNA isolated from urine has the potential to be used to predict, diagnose, and forecast outcomes related to malignant tumors with genetic or epigenetic modifications. Our current projects are (1) to study the K-ras, APC, and p53 mutations as genetic urinary markers for the early detection of colorectal cancer and (2) hyper-methylation of the promoter regions of tumor suppressor genes such as hypermethylation of vimentin, integrin alpha 4, APC genes as epigenetic urinary markers for heptocellular carcinoma (primary liver cancer) and colorectal cancer to explore urine DNA based technology for tumor screening, early detection, and disease management.  In addition, we have discovered a novel antisense strand specific hemimethylation on the promoter region of one tumor suppressor gene and interestingly, this hemimethylation appears to be liver and gastric tissue specific.  More studies are ongoing to understand the biological significance of this antisense strand specific methylation.

Publications

Selected Research Publications:

"Detection of hypermethylated vimentin in urine of patients with colorectal cancer"
Song BP, Jain S, Lin SY, Chen Q, Block TM, Song W, Brenner DE and Y-H Su
Journal of Molecular Diagnostics, 14(2): 112-119, 2012.

"Impact of the Location of CpG Methylation within the GSTP1 Gene on Its Specificity as a DNA Marker for Hepatocellular Carcinoma"
Jain S, Chen S, Chang KC, Lin YJ, Hu CT, Boldbaatar B, Hamilton JP, Lin SY, Chang TT, Chen SH, Song W, Meltzer SJ, Block TM and Y-H Su
PLoS One, 7(4): e35789, 2012.

"Development of an assay for detection of HBV 1762T/1764A double mutation in urine of patients with HBV-associated hepatocellular carcinomas"
Lin SY, Jain S, Yu L, Chen S-H, Song W, Block TM, and Y-H Su
InTech chapter ”Hepatocellular Carcinoma-Clinical Research” p139-154, 2012.

"Detection of hypermethylated vimentin in urine of patients with colorectal cancer"
Song BP, Jain S, Lin SY, Chen Q, Block TM, Song W, Brenner DE, Su Y-H
The Journal of Molecular Diagnostics, Volume 14, Issue 2 , Pages 112-119, March 2012

"Only Methylation of the CpG Sites on the Sense Strand of the APC Gene is Specific for Hepatocellular Carcinoma"
Jain S, Chang T-T, Hamilton JP, Lin SY, Chen S, Lin Y-J, Evans AA, Selaru FM, Lin P-W, Chen S-H, Song W, Block TM, Meltzer SJ, and Y-H Su
PLoS One, 6: e26799, 2011.

"A Locked Nucleic Acid Clamp-Mediated Polymerase Chain Reaction Assay for Detection of a P53 Codon 249 Hotspot Mutation in Urine"
Lin SY, Dhillon V, Jain S, Chang T-T, Hu C-T, Lin Y-J, Chen S-H, Song W, Yu L, Block TM and Y-H Su
Journal of Molecular Diagnostics 13: 474-484, 2011.

"Urinary glycan markers for disease"
Alonzi DS Su Y-H, and TD Butter
Biochem Soc Trans., 39(1): 393-398, 2011.

"Beta interferon plus gamma interferon efficiently reduces acyclovir-resistant herpes simplex virus infection in mice in a T-cell-independent manner"
Huang W-Y, Su Y-H, Yao H-W, Ling P, Tung Y-Y, Chen S-H, Wang X, and S-H Chen.
J. Gen. Virology, 91: 591–598, 2010.

"Rapid and sensitive detection of HBV 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes"
Ren XD, Lin SY, Wang X-H, Tailun Z, Block TM, And Y-H Su.
J. Virological Methods, 158: 24–29, 2009.

"Detection of mutated K-ras DNA in urine, plasma and serum from patients with colorectal carcinoma or adenomatous polyps"
Su Y-H, Wang M, Brenner DE, Norton PA, and TM Block.
Ann. N. Y. Acad. Sci., 1137(1): 197-206, 2008.

"Removal of high molecular weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine"
Su Y-H, Song J, Wang Z, Wang X-H, Aiamkitsumrit B, Wang M, Brenner DE, and TM Block.
Ann. N. Y. Acad. Sci., 1137(1): 82-91, 2008.

"Evidence that the immediate early gene product ICP4 is necessary for HSV-1 DNA circularization in infected cells"
Su Y-H, Zhang X, Block TM and NW Fraser.
Journal of Virology, 80(23): 11589-11597, 2006.

"Detection of K-ras mutation in urine of patients with colorectal cancer"
Su Y-H, Wang M, Aiamkitsumrit B, Brenner DE, and TM Block.
Cancer Biomarkers, 1: 177-182, 2005.

"Preferential Isolation of Fragmented DNA Enhances the Detection of Circulating Mutated k-ras DNA"
Wang M, Block TM, Steel LB, Brenner DE, And Y-H Su.
Clinical Chemistry, 50(1): 211-213, 2004.

"Human urine contains small, 150-250 nucleotide sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer"
Su Y-H, Wang M, Brenner DE, Ng A, Melkonyan H, Umansky S, Syngal S And TM Block.
Journal of Molecular Diagnostics, 6: 101-107, 2004.

"Transrenal DNA as a diagnostic tool: important technical notes"
Su Y-H, Wang M, Block TM, Landt O, Botezatu I, Serdyuk O, Lichtenstein A, Melkonyan H, Tomei LD And S Umansky.
Ann. N. Y. Acad. Sci. 1002: 81-89, 2004.

Teaching

Dr. Su is an associate professor in the Department of Microbiology & Immunology at Drexel University College of Medicine.

Research Location

Drexel Institute for Biotechnology and Virology Research
3805 Old Easton Road
Doylestown, PA 18902
Phone: 215-489-4907
Fax: 215-489-4920

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