The Molecular Genomics Core Facility, which is operated within the Department of Microbiology and Immunology at the Queen Lane Campus, provides support for microarray analyses. The microarray facility is fully operational and was established to assist investigators at Drexel University College of Medicine in the rapidly expanding field of genomics and gene-expression profiling.
The facility contains a 32-pin microarrayer having the capability to print up to 20,000 spots per slide, a dual laser fluorescent scanner and associated software, several 96-well and 384-well thermo-cyclers and a robotic machine dedicated to high throughput liquid handling. This equipment allows the generation, analysis and processing of large numbers of PCR products for arraying or the direct arraying of synthetic oligonucleotides.
At present, investigators are using slides of Plasmodium oligonucleotides and PCR products, mouse oligonucleotides and rat PCR products. Plans are also being considered to array human and yeast sequences.
Technical assistance is available for the preparation of PCR products, preparation of RNA samples, target labeling, array construction, hybridization of microarrays, data collection and bioinformatic analysis.
Additionally, housed at the MGL, is the University's DNA Sequencing Center. Using fluorescent dye termination technology, the center generates DNA sequence information for investigator-generated samples of plasmid DNA or PCR products with a 24-48 hour turnaround.
For more information, please contact Dr. Lawrence Bergman by email or by phone at 215-991-8376.