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Drug Discovery and Development (Pharmacology 525)
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Drug Discovery and Development (Pharmacology 525)

Course Directors: James E. Barrett, Ph.D. & Janet E. Clark, Ph.D.

 

Fall Term 2011
Tuesdays & Thursdays
12:30pm - 2:30pm
Room 4219, New College Building (unless otherwise noted)

Date Time Lecture Faculty
Tuesday
8/23/2011
12:30pm - 2:30pm Course Overview & Objectives
The Drug Discovery, Development & Approval Process

Historical Perspectives: The Legacy of the Past and the Evolution of Drug Discovery & Modern Medicine
Barrett


Clark
Thursday
8/25/2011
12:30pm - 2:30pm Drug Research Strategy: Organizational Aspects of the Pharmaceutical Industry and Addressing Unmet Medical Needs

Central Nervous System Drug Discovery
Williams
Tuesday
8/30/2011
12:30pm - 2:30pm Target Based Drug Discovery: Diversity of Targets, Identification, Selection and Validation Ring
Thursday
9/1/2011
 NO  CLASSES
Tuesday
9/6/2011
12:30pm - 2:30pm High Throughput Screening: Sample Libraries, Hit Identification

Lead Identification & Lead Optimization
Bednar

Murphy
Thursday
9/8/2011
12:30pm - 2:30pm Computational Modeling

Chemical and Biological Space: Medicinal Chemistry and Structure-Activity Relationships
Kortagere

Adejare
Tuesday
9/13/2011
12:30pm - 2:30pm Preclinical Assessment I: In Vivo Model Systems

Predictive Utility of Animal Models
McGonigle 

Rosenzweig-Lipson
Thursday
9/15/2011
12:30pm - 2:30pm Case Study in Drug Discovery and Development I: Modafinil Vaught
Tuesday
9/20/2011
12:30pm - 2:30pm Preclinical Assessment II: Safety and Toxicology

Biologics
Derelanko

Chen
Thursday
9/22/2011

12:30pm - 2:30pm

Clinical Trial Design

Bioinformatics in Drug Discovery & Development
Voralu

Gipson
Tuesday
9/27/2011
12:30pm - 2:30pm Clinical Research I: Phase I Studies First in Humans: Safety & Tolerability Paul
Thursday
9/29/2011
12:30pm - 2:30pm Biologics Chen
Tuesday
10/4/2011
12:30pm - 2:30pm Clinical Research II: Phase II Studies & Clinical Trial Designs Block
Thursday
10/6/2011
 NO CLASS - DISCOVERY DAY
Tuesday
10/11/2011
12:30pm - 2:30pm Current Status & Emerging Trends in the Pharmaceutical & Biotechnology Industry Hargreaves
Thursday
10/13/2011
12:30pm - 2:30pm Clinical Research III: Phase III Studies: Safety and Efficacy Mangano
Tuesday
10/18/2011
12:30pm - 2:30pm Therapeutic Treatment & Unmet Needs I: Oncology Frost

Thursday
10/20/2011

12:30pm - 2:30pm Overview of Pharmacogenetics: Personalized Medicine

Bioinformatics
Stone

Gipson
Tuesday
10/25/2011
12:30pm - 2:30pm In Vivo Antinfective Drug Screening and Evaluation

Patent Law in the Pharmaceutical Industry
Khan

Blass
Thursday
10/27/2011
12:30pm - 2:30pm Translational & Experimental Medicine: Use of Pharmacodynamic Markers & Biomarkers in Drug Discovery & Development Potter
Tuesday
11/1/2011
12:30pm - 2:30pm Project Team Formation: Mock Discovery and Development Project Antal
Thursday
11/3/2011
12:30pm - 2:30pm Beyond Small Molecules: RNAi Therapeutics

Vaccines
Lubbers

Kutzler
Tuesday
11/8/2011
12:30pm - 2:30pm The FDA: Regulatory Guidelines and Drug Development: History and Current Status

Post-marketing Surveillance
Basseches

Killion
Thursday
11/10/2011
12:30pm - 2:30pm Case Study in Drug Discovery and Development II: Carvedilol for the Treatment of Heart Failure Ohlstein
Tuesday
11/15/2011
12:30pm - 2:30pm Overview of Commercial and Marketing Cannon
Thursday
11/17/2011
12:30pm - 2:30pm SPECIAL CLASS: Project Team Presentations
(Room 8312 - NCB)
Antal
Monday
11/21/11
12:30pm - 2:30pm

Case Study in Drug Discovery and Development III: Januvia
(Room 8312 - NCB)

hornberry
Tuesday
11/22/2011
12:30pm - 2:30pm Case Study in Drug Discovery and Development IV: Entereg. for the Treatment of Postoperative Ileus Techner
Thursday
11/24/2011
12:30pm - 2:30pm Current Status and Future Trends in the Pharmaceutical Industry
Round Table Discussion
(Room - 8312 - NCB)
Barrett
Clark

 

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