 Ewing’s sarcoma
Definition Alternative Names Causes, incidence, and risk factors Symptoms Signs and tests Treatment Support Groups Expectations (prognosis) Complications Calling your health care provider References DefinitionEwing's sarcoma is a malignant (cancerous) bone tumor that affects children. Alternative NamesEwing's family of tumors; Primitive neuroectodermal tumors (PNET) Causes, incidence, and risk factorsEwing's sarcoma can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. It is 10 times as common in Caucasian children as in African-American, African, and Asian children. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. The tumor often spreads (metastasis) to the lungs and other bones. Metastasis at the time of diagnosis is present in approximately one-third of children with Ewing's sarcoma. Rarely, Ewing's sarcoma can occur in adults. SymptomsThere are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Children may also break a bone at the site of the tumor after a seemingly minor injury (this is called a "pathologic fracture"). Fever may also be present. Signs and testsIf a tumor is suspected, tests to locate the primary tumor and any spread (metastasis) often include: TreatmentTreatment should be done by a cancer specialist (oncologist) and often includes a combination of: Support GroupsFor additional information and resources, see cancer support group. Expectations (prognosis)The prognosis depends on the location of the tumor, and whether or not the cancer has spread. The best chance for cure is with a combination of treatments that includes chemotherapy plus radiation or surgery, provided at an institution that frequently treats this type of cancer. ComplicationsThe treatments needed to fight this disease have many complications, which should be discussed on an individual basis. Calling your health care providerCall your health care provider if your child has any of the symptoms of Ewing's sarcoma. An early diagnosis can increase the possibility of a favorable outcome. ReferencesBaker LH. Bone tumors: primary and metastatic bone lesions. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 212. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Bone Cancer. National Comprehensive Cancer Network; 2010. Version 1.2010.
Review Date: 3/2/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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